Abstract: Objective To optimize the extraction process of white peony root and scutellaria radix in Yingui kangxian tablets. Methods Taking the concentration and consumption of ethanol, extraction times, extraction time as factors, the paeoniflorin content as index, the L9(34) orthogonal test was adopted to optimize alcohol extraction of seven Chinese herbs including white peony root. Taking the amount of water,extraction times,extraction time as factors,with the baicalin content as evaluation, orthogonal test was similarly adopted to optimize water extraction process of six Chinese herbs. Results The best alcohol extraction conditions with white peony root were as follows: extracted three times with ten times the amount of 75% ethanol, 1.5 hours per time. Optimum water extraction conditions with scutellaria radix were as follows: extracted three times with eight times the volume of water, 2 hours per time. Conclusion Optimized extraction process was stable and feasible, which could provide a reference for rational development of Yingui kangxian tablets.

Key words: Yingui kangxian tablets, orthogona1 test, extraction technology