Chinese Journal of Pharmacovigilance ›› 2013, Vol. 10 ›› Issue (9): 567-570.

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Study of Compatible Stability on Salvia Injection and Transfusion

LIN Xiao -ming1, HUANG Min2 ,ZHU Jian3   

  1. 1.People's Hospital of Guigang City, Guangxi Guigang 537100, China;
    2.The First Affiliated Hospital of Guangxi Traditional Chinese Medicine University, Guangxi Nanning 530023, China;
    3.Guangxi National Hospital,Guangxi Nanning 530001, China
  • Received:2013-04-15 Revised:2016-03-09 Online:2013-09-08 Published:2016-03-09

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Abstract: Objective To investigate the effect of multiple factors on compatible stability in salvia injection and transfusion so as to achieve the optimal program. Methods The particle content was measured by GWF-5J particle analyzer with orthogonal test, and the particles in solution and protocatechuic aldehyde content were used as indicators. The protocatechuic aldehyde content in solution was determined by HPLC. Results Effect of compatible temperature and stored time on protocatechuic aldehyde content was statistically significant. In addition, effect of dose on particle content in solution was statistically significant. Conclusion The optimal compatible match of salvia injection was to combine with 100 mL sodium chloride injection at 25℃ for 2 hours.

Key words: salvia injection, insoluble particle, protocatechuic aldehyde, orthogonal test

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