Research Development on Toxicity of Tripterygium silfordii Related to Efficacy and Chemical Material Basis

Abstract

Abstract: Objective To provide literature evidences and research ideas of efficacy and toxicity of the chemical composition of guided separation, control and efficacy, and the research on the "dose-effect relationship" and "dosetoxicity relationship" about the toxical components. Methods References in old days and in the last decades both at home and abroad about Tripterygium silfordii were collated, analyzed and summarized. Results and Conclusion The research on Tripterygium silfordii about the toxicity and margin of safety control based on the chemical separation and quality control about the effective material basis combined with the process of the effectiveness of expression, so as to provide consummating safety standards and putting forward early-warning scheme of adverse reaction, the early diagnosis and treatment measures that can be referred to clinical usage. Tripterygium silfordii will be ensured to use safely asa clinical drug.

Key words: Tripterygium silfordii , efficacy, material basis, toxicity

CLC Number:

R282R285.5

FENG Qun ,LUAN Yong-fu ,SUN Rong. Research Development on Toxicity of Tripterygium silfordii Related to Efficacy and Chemical Material Basis [J]. Chinese Journal of Pharmacovigilance, 2013, 10(2): 88-91.

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