Abstract: Objective To evaluate application of antibacterials in our hospital inpatients. Methods By retrospective study, the data of drug used in 2011 were collected and analyzed. Taking defined daily dose(DDD) as the unit, antibacterials use density(AUD) was calculated and analyzed. Results The mean value of AUD was 61.49 The third generation cephalosporins, the second generation cephalosporins and quinolones were in the top 3 places respectively .The top three drugs of AUD were cefoperazone/sulbactum, cefepime and cefuroxime.Conclusion There are such problems as over medication and use of high-class antibacterials at our hospital. Thus, the management of antibacterials should be strengthened.