Abstract: Objective To investigate the relationship of oxidative damage mechanism in hepatical toxical injury caused by different components from Folium Artemisiae Argyi in mice. Methods Mice were administrated with water extracted and volatile oil components according to 7 days toxicity test method. The level of MDA、SOD、NO、NOS、GSH、GSH-Px in serum and hepatic tissue were detected. Results The different components can cause the activity of MDA in serum and liver increased, the level of SOD corresponding induced, however the level of NO and NOS were increased. In addition the activity of GSH and GSH-Px reduced. All the changes were aggravated in accordance with the dosages. Conclusion The continuous administration of different components from Folium Artemisiae Argyi to mice can induce obvious hepato-toxicity injury, the approach of hepatic damage is related with the peroxidative damage mechanism.

Key words: Folium Artemisiae Argyi, water extracted and volatile oil components, hepato-toxicity, oxidative damage mechanism