Abstract: Objective To study the inhibitory effect of Radix seutellariae on genetic damage induced by CdSO4 and MMC in mice. Methods The micronucleus test of mouse bone marrow cell(MNT) was used, to detect the micronucleus rate in mouse bone marrow cell, and to analysis the micronucleus rates by the statistical compution. Results The frequency of micronucleus in mouse bone marrow induced by CdSO4 and MMC in mice was reduced significantly, showed significant difference(P <0.01). There is no significant difference in there groups of Radix Seutellariae and CdSO4 at the same time( P>0.05). Conclusion Radix Seutellariae has the effect of antimutation under the experimental conditions,and it may be an antimutagen.

Key words: Radix Seutellariae, micronucleus test, antimutation