Abstract: Objective To review the integrative mechanisms by which Traditional Chinese Medicine combats gastric ulcer by regulating multiple signaling pathways and gut microbiota and inducing synergistic interactions between these two systems so as to provide data for clinical research. Methods Related databases were searched for studies published in recent years on the regulation of signaling pathways related to gastric ulcer and to the modulation of gut microbiota structure and function mediated by Traditional Chinese Medicine. The included studies were analyzed by focusing on the mechanisms underlying inflammatory responses and gastric mucosal repair. Results By regulating multiple signaling pathways, Traditional Chinese Medicine can not only alleviate inflammation and promote the proliferation and repair of gastric mucosal epithelial cells, but also modulate gut microbiota composition, restore microbial homeostasis, and enhance mucosal barrier function. Bidirectional interactions were observed between signaling pathways and gut microbiota, forming an integrated network that contributed to synergistic mucosal repair. Conclusion Traditional Chinese Medicine can be used to treat gastric ulcer through integrative mechanisms involving multiple targets, multiple pathways, and gut microbiota regulation. This study is expected to offer new lines of thought for future research.

Key words: Traditional Chinese Medicine, Gastric Ulcer, Signal Pathway, Intestinal Flora, Integration Mechanism