Abstract: Objective To explore the applicability of ^99mTc-ECD cerebral perfusion SPECT/CT fusion imaging in ischemic cerebrovascular diseases. Methods The clinical data of 112 patients clinically diagnosed with ischemic cerebrovascular diseases was collected. Computed tomography angiography (CTA) of the head and neck revealed varying degrees of vascular stenosis. All the patients underwent ^99mTc-ECD cerebral perfusion SPECT/CT imaging within 5 days of onset. The detection rate, range, and positive rate of lesions were compared and analyzed between SPECT/CT fusion images, pure SPECT perfusion images, and CT images. The positive rates of different imaging methods were analyzed using the McNemar test, with P <0.05 indicating statistical significance. Results None of the 112 patients experienced significant discomfort during ^99mTc-ECD imaging. The positive rate of SPECT/CT fusion imaging was 100%, with 381 ischemic or infarct lesions detected, compared with 98.21%, and 316 for SPECT perfusion imaging and 67.86% and 192 for CT imaging. Statistical analysis showed no significant difference in the diagnostic positive rate between SPECT/CT fusion images and pure SPECT images. However, both SPECT/CT fusion images and pure SPECT images had significantly higher diagnostic positive rates than CT images (P <0.05). Conclusion ^99mTc-ECD cerebral perfusion imaging is safe and convenient. SPECT/CT fusion imaging is superior to SPECT cerebral perfusion imaging and CT imaging in terms of the detection range, number, and positive rate of lesions in patients with ischemic cerebrovascular disease.

Key words: ^99mTc-ECD, Cerebral Blood Flow Perfusion, Ischemic Cerebrovascular Disease, SPECT/CT