[1] FORMAN BM, GOODE E, CHEN J, et al.Identification of a nuclear receptor that is activated by farnesol metabolites[J]. Cell, 1995, 81(5): 687-693. [2] WANG H, CHEN J, HOLLISTER K, et al.Endogenous bile acids are ligands for the nuclear receptor FXR/BAR[J]. Mol Cell, 1999, 3(5): 543-553. [3] TEODORO JS, ROLO AP, PALMEIRA CM.Hepatic FXR: key regulator of whole-body energy metabolism[J]. Trends Endocrinol Metab, 2011, 22(11): 458-466. [4] WANG YD, CHEN WD, MOORE DD, et al.FXR: a metabolic regulator and cell protector[J]. Cell Res, 2008, 18(11): 1087-1095. [5] LEE FY, LEE H, HUBBERT ML, et al.FXR a multipurpose nuclear receptor[J]. Trends Biochem Sci, 2006, 31(10): 572-580. [6] DÜFER M, HÖRTH K, KRIPPEIT-DREWS P, et al. The significance of the nuclear farnesoid X receptor (FXR) in β cell function[J]. Islets, 2012, 4(5): 333-338. [7] HUANG W, MA K, ZHANG J, et al.Nuclear receptor-dependent bile acid signaling is required for normal liver regeneration[J]. Science, 2006, 312(5771): 233-236. [8] YANG F, HUANG X, YI T, et al.Spontaneous development of liver tumors in the absence of the bile acid receptor farnesoid X receptor[J]. Cancer Res, 2007, 67(3): 863-867. [9] WILKINS T, AGABIN E, VARGHESE J, et al.Gallbladder dysfunction:cholecystitis, choledocholithiasis, cholangitis, and biliary dyskinesia[J]. Prim Care, 2017, 44(4): 575-597. [10] LI JX, CHEN J, LIANG J.Consensus on diagnosis and treatment of cholelithiasis with integrated traditional Chinese and Western Medicine(2017)[J]. Chin J Integr Trad West Med Dig(中国中西医结合消化杂志), 2018, 26(2): 132-138. [11] BARBAZUK WB, KORF I, KADAVI C, et al.The syntenic relationship of the zebrafish and human genomes[J]. Genome Res, 2000, 10(9): 1351-1358. [12] MACRAE CA, PETERSON RT.Zebrafish as tools for drug discovery[J]. Nat Rev Drug Discov, 2015, 14(10): 721-731. [13] HÖLTTÄVUORI M, SALO VT, NYBERG L, et al. Zebrafish: gaining popularity in lipid research[J]. Biochem J, 2010, 429(2): 235-242. [14] WANG Q, WEN HR, MA SC. Hepatotoxic components screening in polygonum multiflorum by taking fxr nuclear receptors as Targets[J/OL]. [2022-04-10]. Chinese Journal of Pharmacovigilance(中国药物警戒). https://kns-cnki-net.web.bisu.edu.cn/kcms/detail/11.5219.R.20210913.1900.011.html. [15] JIANG C, XIE C, LYU Y, et al.Intestine-selective farnesoid X receptor inhibition improves obesity-related metabolic dysfunction[J]. Nat Commun, 2015, 6: 10166. [16] KJÆRGAARD K, FRISCH K, SØRENSEN M, et al. Obeticholic acid improves hepatic bile acid excretion in patients with primary biliary cholangitis[J]. J Hepatol, 2021, 74(1): 58-65. [17] CARINO A, BIAGIOLI M, MARCHIANÒ S, et al.Ursodeoxycholic acid is a GPBAR1 agonist and resets liver/intestinal FXR signaling in a model of diet-induced dysbiosis and NASH[J]. Biochim Biophys Acta Mol Cell Biol Lipids, 2019, 1864(10): 1422-1437. [18] DONG LC, FAN YX, YU Q, et al.Synergistic effects of rhubarb-gardenia herb pair in cholestatic rats at pharmacodynamic and pharmacokinetic levels[J]. J Ethnopharmacol, 2015, 175: 67-74. [19] HORZMANN KA, FREEMAN JL.Making waves: new developments in toxicology with the zebrafish[J]. Toxicol Sci, 2018, 163(1): 5-12. [20] IKEGAMI T, MATSUZAKI Y.Ursodeoxycholic acid: Mechanism of action and novel clinical applications[J]. Hepatol Res, 2008, 38(2): 123-131. [21] FUJITA K, IGUCHI Y, UNE M, et al.Ursodeoxycholic acid suppresses lipogenesis in mouse liver: possible role of the decrease in β-muricholic acid, a farnesoid X receptor antagonist[J]. Lipids, 2017, 52(4): 335-344. [22] AROSIO B, GAGLIANO N, FUSARO LM, et al.Aloe-emodin quinone pretreatment reduces acute liver injury induced by carbon tetrachloride[J]. Pharmacology & Toxicology, 2000, 87(5), 223-229. [23] SHENG X, ZHU X, ZHANG Y, et al.Rhein protects against obesity and related metabolic disorders through liver X receptor-mediated uncoupling protein 1 upregulation in brown adipose tissue[J]. Int J Biol Sci, 2012, 8(10): 1375-1384. [24] XIAN Z, TIAN J, WANG L, et al.Effects of rhein on bile acid homeostasis in rats[J]. Biomed Res Int, 2020, 2020: 8827955. [25] XIONG XL, DING Y, CHEN ZL, et al.Emodin rescues intrahepatic cholestasis via stimulating FXR/BSEP pathway in promoting the canalicular export of accumulated bile[J]. Front Pharmacol, 2019, 10: 522. [26] TANAKA A, HIROHARA J, NAKANUMA Y, et al.Biochemical responses to bezafibrate improve long-term outcome in asymptomatic patients with primary biliary cirrhosis refractory to UDCA[J]. J Gastroenterol, 2015, 50(6): 675-682. [27] BOWLUS CL, POCKROS PJ, KREMER AE, et al.Long-term obeticholic acid therapy improves histological endpoints in patients with primary biliary cholangitis[J]. Clin Gastroenterol Hepatol, 2020, 18(5): 1170-1178. |