Determination of Silicon in Pantoprazole Sodium for Injection by ICP-MS

doi:10.19803/j.1672-8629.2021.07.03

Abstract

Abstract: Objective To establish a method for the determination of silicon in pantoprazole sodium for injection. Methods Inductively coupled plasma mass spectrometry (ICP-MS) was used to determine the contents of silicon, while ⁴⁵Sc was used as the internal standard of ²⁸Si. Results The linear ranges of Si was 100-5 000 ng/mL. The r value was 0.999 9. The RSD of precision was 0.7%, compared to 1.0% for the repeatability test, and 1.1% for intermediate precision. The average recovery rate of low, medium and high concentrations was 102.3% (n=9). Conclusion This method is accurate and sensitive, which can be used for determination of Si in pantoprazole sodium for injection.

Key words: pantoprazole sodium, inductively coupled plasma mass spectrometry, silicon, assay

CLC Number:

R917

DUAN Xiying, WANG Dongyun, XU Jia, QIU Yajing, XU Mingzhe. Determination of Silicon in Pantoprazole Sodium for Injection by ICP-MS[J]. Chinese Journal of Pharmacovigilance, 2021, 18(7): 611-613.

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