中国药物警戒 ›› 2014, Vol. 11 ›› Issue (9): 513-515.

• 基础研究 •    下一篇

一叶抗流感胶囊解热、抗炎、镇痛的药效学研究

郭姗姗1, 马雪萍2, 高英杰1, 金亚宏1, 崔晓兰1*   

  1. 1中国中医科学院中药研究所,北京 100700;
    2新疆维吾尔自治区药物研究所,新疆 乌鲁木齐830004
  • 收稿日期:2014-06-19 修回日期:2016-02-03 出版日期:2014-09-08 发布日期:2016-03-02
  • 作者简介:郭姗姗,女,博士,助理研究员,中药药理学。
  • 基金资助:
    基金项目：国家重大新药创制项目（2011ZX09102-009-07-01）

Pharmacodynamic Study on Antipyretic, Anti-inflammatory and Analgesic Effects of Yiye Anti-influenza Capsules

GUO Shan-shan1, MA Xue-ping2, GAO Ying-jie1, JIN Ya-hong1, CUI Xiao-lan1, *   

  • Received:2014-06-19 Revised:2016-02-03 Online:2014-09-08 Published:2016-03-02

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摘要： 目的评价一叶抗流感胶囊的药效作用。方法通过大鼠酵母致热实验观察其解热作用;热板法和扭体法观察其镇痛作用;小鼠腹腔注射醋酸致毛细血管通透性增高实验观察其抗炎作用。结果高、中剂量组能明显抑制的酵母所致大鼠体温升高、降低小鼠的扭体次数和延长1 h热刺痛引起的痛阈值,一叶抗流感胶囊还能明显的抑制醋酸所致毛细血管通透性的增加。结论一叶抗流感胶囊具有良好的解热、镇痛和抗炎的作用。

关键词: 一叶抗流感胶囊, 解热, 镇痛, 抗炎

Abstract: Objective To evaluate the pharmacodynamic effects of Yiye anti-influenza capsules (YYAFC). Methods The relieving fever effect was observed on Saccharomyces siccum induced fever model of rats; the analgesic effect was investigated by hot plate method and body twist method; the anti-inflammatory effect was observed by the capillary permeability augmentation of mice induced by acetic acid. Results High-dose and medial-dose of YYAFC could significantly decrease the raised body temperature caused by Saccharomyces siccum in rats, depress the torsion body of mice and increased the pain thresholds for 1 hour(P < 0.05). It also could significantly inhibit capillary permeability augmentation caused by acetic acid in mice. Conclusion YYAFC has better effects on relieving fever, analgesia and anti-inflammation.

Key words: Yiye anti-influenza capsules, relieving fever, analgesia, anti-inflammation

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