中国药物警戒 ›› 2014, Vol. 11 ›› Issue (6): 325-327.

• 基础与临床研究 • 上一篇    下一篇

金黄止咳颗粒的止咳化痰抗炎作用实验研究

杨鸿1, 孔冬冬2*   

  1. 1中国中医科学院医学实验中心,北京 100700;
    2灵武市中医医院药剂科,宁夏 灵武 751400
  • 收稿日期:2013-12-13 修回日期:2016-02-03 出版日期:2014-06-08 发布日期:2016-03-02
  • 通讯作者: 孔冬冬,本科,副主任药师,中药复方及其配伍的药效及
  • 作者简介:杨鸿,博士,副研究员,中药复方及其配伍的分子机制研究。

Pharmacological Study of Jinhuang Zhike Granule on Relieving A Cough, Abolishing Phlegm and Anti-inflammation

YANG Hong1, KONG Dong-dong2, *   

  1. 1Experimental Research Center, China Academy of Chinese Medical Science, Beijing 100700, China;
    2Lingwu Chinese Medicine Hospital,Ningxia Lingwu 100700, China
  • Received:2013-12-13 Revised:2016-02-03 Online:2014-06-08 Published:2016-03-02

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摘要： 目的观察金黄止咳颗粒的止咳、化痰和抗炎作用。方法分别采用小鼠氨水引咳法、豚鼠枸橼酸引咳法观察金黄止咳颗粒止咳作用,气管酚红排泌法观察其化痰作用,及小鼠二甲苯耳肿胀法和大鼠角叉菜胶性足肿胀法观察其抗炎作用。结果金黄止咳颗粒可明显延长小鼠和豚鼠的咳嗽潜伏期和减少咳嗽次数;显著增加小鼠呼吸道黏膜酚红的排出量,对二甲苯和角叉菜胶所致急性炎症反应有很好的抑制作用。结论金黄止咳颗粒具有明显的止咳、化痰和抗炎作用。

关键词: 金黄止咳颗粒, 止咳, 化痰, 抗炎

Abstract: ObjectiveTo observe the cough relieving, sputum elimination and anti-inflammation effects of Jinhuang Zhike Granule(JHZK). MethodsThe cough relief effect of JHZK was observed by ammonia water causing cough in mice and citric acid causing cough in guinea pigs. The sputum elimination effect of JHZK was studied by the observation of tracheal phenol red shedding in mice. The anti-inflammatory effect was tested by xylene swelling inducing on mice and rat's toe swelling test caused by carrageen. ResultsJHZK could significantly inhibit the incubation period and cough frequency of the model mice and guinea pigs induced by ammonia water and citric acid, and notably improve the tracheal phenol red excretion volume in mice, and inhibit acute inflammatory response in mice and rat respectively induced by xylene and carrageen. ConclusionJHZK has certain effects of cough relief, sputum elimination and anti-inflammatory effects.

Key words: Jinhuang Zhike Granule, relieving cough, reducing sputum, anti-inflammation

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