适宜于中药抗急性肝损伤活性发现与药效评价的动物模型应用概况

中国药物警戒 ›› 2015, Vol. 12 ›› Issue (11): 669-673.

适宜于中药抗急性肝损伤活性发现与药效评价的动物模型应用概况

黄娜娜^{1, 2}, 孙蓉^1*

1山东省中医药研究院,山东济南,250014；
2山东中医药大学,山东济南,250355

收稿日期:2016-02-02 修回日期:2016-02-02 出版日期:2015-11-08 发布日期:2016-02-02
通讯作者: 孙蓉,女,博士,研究员·博导,中药药理与毒理。E-mail：sunrong107@163.com
作者简介:黄娜娜,女,在读硕士,中药药理与毒理。
基金资助:
山东省自主创新和成果转化项目（2014ZZCX02104）; 国家自然科学基金面上项目（81374059）

Application of Animal Models for the Discovery and Efficacy Evaluation of Anti Acute Liver Injury in Chinese Medicine

HUANG Na-na^{1, 2}, SUN Rong^{1, *}

1Shandong Academy of Chinese Medicine, Shandong Jinan 250014, China;
2 .Shandong University of Traditional Chinese Medicine, Shandong Jinan 250014, China

Received:2016-02-02 Revised:2016-02-02 Online:2015-11-08 Published:2016-02-02

摘要/Abstract

摘要： 目的总结近年来不同因素造成动物急性肝损伤模型的应用概况,并将其用于中医病证研究和中药药效评价的契合程度与准确性高低进行评价与思考,以期寻求更好地适宜于不同证型急性肝损伤的中医药研究动物模型。方法对近十几年来国内外相关文献对急性肝损伤模型的报道进行整理、分析与归纳。结果目前常见的模型多为西医病理模型（主要有化学性、药物性、免疫性和酒精性等急性肝损伤模型）,而中医病证动物模型的研究报道较少,都还不能完全反映急性肝损伤这类疾病的本质,从而也影响了治疗急性肝损伤药物的合理评价。结论为了更好地研究急性肝损伤的本质和提供更好的保肝药的评价工具,应在中医理论指导下,以中医临床上急性肝损伤的表现为依据,结合现代病因、病机研究,研制更符合临床实际和中医理论的急性肝损伤病证结合动物模型。

关键词: 急性肝损伤, 动物模型, 药效评价

Abstract: Objective To summarize the research progress on acute liver injury (ALI) caused by different factors of animal models in recent years, which will be used for TCM syndromes study and efficacy evaluation, and assess the degree of fit and accuracy between them, in order to seek better animal models of medical research adapted to different syndromes of ALI. Methods References about ALI model in the last decades at home and abroad were collated, analyzed and summarized. Results At present the common model is modern pathology model (model of ALI is mainly chemical, drug, alcohol and other autoimmune), but few studies have reported an animal model of TCM syndrome, and all of these failed to fully reflect the nature of these diseases in ALI, thus also affected the reasonable evaluation of drugs for acute liver injury. Conclusion In order to study the nature of ALI and liver medicine to provide better tools for evaluation. Under the guidance of Chinese medicine theory, on the basis of TCM clinical manifestations of ALI , combining modern etiology and pathogenesis study, we should research ALI animal model which is more in line with actual clinical syndromes and TCM theory.

Key words: acute liver injury, animal model, efficacy evaluation

中图分类号:

黄娜娜, 孙蓉. 适宜于中药抗急性肝损伤活性发现与药效评价的动物模型应用概况[J]. 中国药物警戒, 2015, 12(11): 669-673.

HUANG Na-na, SUN Rong. Application of Animal Models for the Discovery and Efficacy Evaluation of Anti Acute Liver Injury in Chinese Medicine[J]. Chinese Journal of Pharmacovigilance, 2015, 12(11): 669-673.

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