中国药物警戒 ›› 2015, Vol. 12 ›› Issue (8): 458-461.

• 基础研究 • 上一篇    下一篇

布洛芬注射液的特殊安全性评价

曹冲1, 高梅1, 杨麟珂2, 张婷婷2   

  1. 1. 山东省药学科学院山东省化学药物重点实验室,山东 济南 250101;
    2. 山东省肿瘤医院,山东 济南 250000
  • 收稿日期:2015-09-02 修回日期:2015-09-02 出版日期:2015-08-08 发布日期:2015-09-02
  • 作者简介:曹冲,男,本科,工程师,药学。

Special Safety Evaluation on Ibuprofen Injection

CAO Chong1, GAO Mei1, YANG Lin-ke2, ZHANG Ting-ting2   

  1. 1. Shandong Academy of Pharmaceutical Sciences, Shandong Provincial Key Laboratory of Chemical Drug, Shandong Jinan 250101, China;
    2. Shandong Cancer Hospital and Institute, Shandong Jinan 250000, China
  • Received:2015-09-02 Revised:2015-09-02 Online:2015-08-08 Published:2015-09-02

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摘要： 目的 通过对布洛芬注射液特殊安全性进行试验研究,评价其用药的安全性。方法 将布洛芬注射液配成适当浓度,分别进行溶血性试验,家兔血管刺激性试验及豚鼠全身过敏性试验,观察布洛芬注射液是否具有溶血作用,是否可引起过敏和对血管的刺激性。结果 布洛芬注射液4 mg·mL-1未见溶血及凝集反应,静脉注射未见明显血管刺激性,25 mg·mL-1给药后未出现过敏反应。结论 布洛芬注射液可供静脉注射试用给药。

关键词: 布洛芬注射液, 溶血性, 血管刺激性, 过敏性

Abstract: Objective To evaluate safety of ibuprofen for injection based on the special safety experiments of ibuprofen injection, Methods Three experiments were used, including hemolysis and blood cell agglutination test in vitro and stimulation test in blood vessel, allergic test induced by ibuprofen injection in guinea pigs, to observe whether ibuprofen injection could induce hypersensitive response, vascular stimulation response, hemolytic reaction and agglutination or not. Results Ibuprofen injection caused no hemolysis and blood cell agglutination when its concentration was 4 mg·mL-1, neither vascular stimulation in rabbits nor allergic reaction in guinea pigs were observed when its concentrations were 4 mg·mL-1 and 25 mg·mL-1 respectively. Conclusion Ibuprofen injection is safe for intravenous injection.

Key words: ibuprofen injection, hemolysis, vascular stimulation, allergic reaction

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