关键词: 狂犬疫苗, 不良反应, 文献分析

Abstract: Objective To discuss the general pattern and characteristics of adverse reactions induced by rabies vaccine, provide references for the observation of adverse reactions induced by rabies vaccine. Methods Adverse reactions induced by rabies vaccine reported in the literature database CNKI from1975~2014 were researched and analyzed statistically. Results A total of 173 related literatures were eligible with 1 855 cases in total. Among these cases, 40.92% occurred mostly in patients aged from 20 to 40 years old. Most adverse reactions (up to 45.56%) took place within 1~12 h after injection of the vaccine, mainly happening after 1st, 3rd, 4th injection. The incidence of adverse reactions for the culture of Vero cells was the highest, accounting for 54.49% with most adverse reactions of skin system, followed by primary hamster kidney cell culture vaccine accounting for 41.46% with most adverse reactions of allergy. The adverse reactions for animal brain tissue vaccine are mainly nervous system complications reaching to 3.49%. Conclusion The causes of adverse reactions induced by rabies vaccine were miscellaneous. Clinicians and pharmacists should pay attention to the clinical use of rabies vaccine. Patients should also be monitored strictly during pre- and post-injection to reduce the incidences of adverse reactions and give rescue timely.

Key words: rabies vaccine, adverse reactions, literature analysis