氟喹诺酮类抗菌药使用频度与常见细菌耐药率的相关研究

中国药物警戒 ›› 2015, Vol. 12 ›› Issue (7): 424-427.

氟喹诺酮类抗菌药使用频度与常见细菌耐药率的相关研究

叶云

安徽省蚌埠市第三人民医院,安徽蚌埠 233000

收稿日期:2015-01-29 修回日期:2015-09-01 出版日期:2015-07-08 发布日期:2015-09-02
作者简介:叶云,男,硕士,抗菌药物合理使用。
基金资助:
2013年蚌埠市医疗卫生类科技计划项目(20130307）

Correlation Analysis of Fluoroquinolone Antibacterial Use and Resistance Rate of Common Bacteria

YE Yun

Bengbu 3rd People's Hospital, Anhui Bengbu 233000, China

Received:2015-01-29 Revised:2015-09-01 Online:2015-07-08 Published:2015-09-02

摘要/Abstract

摘要： 目的统计分析某三甲医院2009~2013年氟喹诺酮类抗菌药使用情况及细菌耐药率,并分析两者之间的相关性,为降低细菌耐药性和合理使用抗菌药提供参考依据。方法采用回顾性调查方法对2009~2013年送检病原菌培养结果、同期抗菌药物累计使用频度和细菌耐药率情况进行统计分析,并利用SPSS 17.0软件统计细菌耐药率和抗菌药物消耗量之间的Pearson积差相关系数。结果氟喹诺酮类抗菌药用药频度从2009年的29237.90 DDDs下降到2013年的11296.65DDDs,累计下降了61.36%。除氟喹诺酮类抗菌药使用与溶血性葡萄球菌（r=-0.68）和屎肠球菌（r=-0.86）耐药率存在负相关外,与常见细菌耐药率存在正相关,其中与大肠埃希菌（r=0.95）、阴沟肠杆菌（r=0.88）及粪肠球菌（r=0.95）耐药率存在显著正相关。结论某院氟喹诺酮类抗菌药物使用频度呈下降的趋势;除溶血性葡萄球菌和屎肠球菌外,氟喹诺酮类抗菌药物的使用与常见病原菌的耐药率呈正相关;提高氟喹诺酮类抗菌药使用频度可能是某些细菌耐药率增高的一大因素。

关键词: 细菌耐药, 氟喹诺酮, 限定日剂量

Abstract: Objective To statistically analyze utilization of fluoroquinolone antibiotic drugs and resistance rate of bacteria in a hospital from 2011 to 2013, and study the relationship between them, so as to reduce bacterial resistance and provide references for clinical rational use of antibacterial drugs. Methods Retrospective investigation method was used to statistically analyze the pathogenic bacteria culture Results, antibacterial cumulative frequency and Results of drug resistance test. SPSS 17.0 software was used to analyze Pearson correlation coefficient of the resistant rates of bacteria and antibacterial consumption. Results The frequency of fluoroquinolone antibacterial drug use decreased from 29 237.90 DDDs in 2009 to 11 296.65 DDDs in 2013, cumulatively declined by 61.36%. In addition to the fluoroquinolone use and Staphylococcus haemolyticus (r=-0.68) and Enterococcus faecium (r=-0.86) resistance rate were negatively correlated, positive correlation has been found with the common bacteria resistance rate, there is a significant positive correlation with E. coli (r=0.95), Enterobacter cloacae (r=0.88) and Enterococcus faecalis (R=0.95). Conclusion The frequency of fluoroquinolone antibacterial drug use showed a declining trend in a hospital. In addition to Staphylococcus haemolyticus and Enterococcus faecium, drug use of fluoroquinolones and common pathogenic bacteria was positively correlated, the frequency of fluoroquinolone antibacterial drug use may be a main factor to increase certain bacteria resistance rate.

Key words: bacterial resistance, fluoroquinolone, Defined Daily Dose

中图分类号:

R965

叶云. 氟喹诺酮类抗菌药使用频度与常见细菌耐药率的相关研究[J]. 中国药物警戒, 2015, 12(7): 424-427.

YE Yun. Correlation Analysis of Fluoroquinolone Antibacterial Use and Resistance Rate of Common Bacteria[J]. Chinese Journal of Pharmacovigilance, 2015, 12(7): 424-427.

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