关键词: 中药注射剂, 不良反应, 文献分析, 合理用药

Abstract: Objective To explore the general pattern and characteristics of adverse reaction induced by seven traditional Chinese medicine injections so as to provide some guidance for clinical rational use of drug. Methods A retrospective analysis was conducted on 607 cases of seven traditional Chinese medicine injections' adverse reaction reported in domestic medical journals included in CHKD database from 1994 to 2010. Results Adverse reaction of seven traditional Chinese medicine injections for cardio-cerebrovascular disease often occurred in the people at the age of over 40 years old. The onest of adverse reaction was usually within 30 minutes after injection. Adverse reaction could involve in multiple organs and systems, and clinical manifestations were various, mainly were allergic reaction. Severe allergic reaction could result in anaphylactic shock. Adverse reaction of every drug had themselves general pattern and characteristics in sex and age and type and so on. Conclusion Doctors and pharmacists should know the pattern and characteristics of adverse reaction, and the use of traditional Chinese medicine injection should be under strict monitoring to reduce the occurrence of serious adverse reaction.

Key words: traditional Chinese medicine injection, adverse reaction, analysis of literature, rational use of drug