中国药物警戒 ›› 2012, Vol. 9 ›› Issue (4): 234-236.

• 药品不良反应监测 • 上一篇    下一篇

注射用萘夫西林、病毒唑配伍使用致儿童药物性溶血性贫血12例分析

陈大奎，唐晓霞，朱雯雯   

  1. 华中科技大学同济医学院附属孝感医院，湖北 孝感 432100
  • 收稿日期:2011-10-09 出版日期:2012-04-10 发布日期:2015-08-10
  • 作者简介:陈大奎，男，主管药师，药品不良反应监测。

Aanlysis of 12 Cases of Children Drug-induced Hemolytic Anemia Caused by Nafcillin and Ribavirin Combinafion

CHEN Da-kui, TANG Xiao-xia, ZHU Wen-wen   

  1. Xiaogan Central Hospital Affiliated toTongji Medical College, Huazhong University of Science and Technology, Hubei Xiaogan 432100, China
  • Received:2011-10-09 Online:2012-04-10 Published:2015-08-10

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摘要： 目的对临床儿童使用注射用萘夫西林、病毒唑配伍致药物性溶血性贫血12例进行分析研究，为临床提供安全性用药依据。方法对我院2011年7月~8月门诊儿科使用注射用萘夫西林情况进行统计分析，对期间发生药物性溶血性贫血（DHA）不良反应进行分析、研究、评估。结果0~5岁儿童因抗感染而使用注射用萘夫西林、病毒唑配伍致药物性溶血性贫血发生率为3.3%，平均发生时间为5.5天，其中男童发生率2.39%，女童发生率5%。结论萘夫西林、病毒唑联合使用应谨慎。对于儿童，尤其是低龄儿童应特别注意严格按照说明书推荐的给药次数用药。

关键词: 萘夫西林, 病毒唑, 药品不良反应, 药物性溶血性贫血

Abstract: Objective To analyze and discuss the drug-induced hemolytic anemia on children caused by the combined use of the injections of nafcillin, ribavirin in 12 cases in clinical, and provide evidence for clinical safe use of medicine. MethodsThe uses of the injectable nafcillin in pediatric outpatient department of our hospital between July and August in 2011 were statistically analyzed, and the adverse reactions of drug-induced hemolytic anemia(DHA) occuring during these were analyzed, researched and assessed. ResultsThe adverse reactions of the drug-induced hemolytic anemia caused by the combination uses of the injectable nafcillin, ribavirin due to resistance to infections on children beween 0~5 years old occurred at a rate of 3.3%, and the average time was 5.5 days, the boys incidence rate was 2.39%, and girls incidence rate was 5%. ConclusionNafcillin, ribavirin combined use should be cautious. For the children, especially younger children should be paid attention strictly in accordance with the instructions to the recommended dosage of medication.

Key words: nafcillin, ribavirin, adverse drug reaction, drug-induced hemolytic anemia