中国药物警戒 ›› 2026, Vol. 23 ›› Issue (9): 1050-1052.
DOI: 10.19803/j.1672-8629.20250670

• 安全与合理用药 • 上一篇    下一篇

注射用尖吻蝮蛇血凝酶致儿童结膜充血2例分析

尚家海1,2, 龙娇娇1,2, 刘雅瑞1, 卢圆圆1,2,*   

  1. 1华中科技大学同济医学院附属湖北妇幼保健院药学部,湖北 武汉 430070;
    2武汉科技大学医学部,湖北 武汉 430065
  • 收稿日期:2025-09-19 出版日期:2026-09-15 发布日期:2026-09-15
  • 通讯作者: *卢圆圆,女,博士,副主任药师,医院药学。E-mail: luyuanyuan200715@163.com
  • 作者简介:尚家海,男,在读硕士,临床药学。
  • 基金资助:
    国家药品监督管理局药品监管科学体系建设重点项目（RS2024G001）

Two cases of conjunctival congestion in children caused by hemocoagulase agkistrodon for injection

Shang Jiahai1,2, Long Jiaojiao1,2, Liu Yarui1, Lu Yuanyuan1,2,*   

  1. 1Department of Pharmacy, Maternal and Child Health of Hubei Province, Tongji Medical College, Huazhong University of Science and Technology, Wuhan Hubei 430070, China;
    2Department of Medicine, Wuhan University of Science and Technology, Wuhan Hubei 430065, China
  • Received:2025-09-19 Online:2026-09-15 Published:2026-09-15

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摘要： 目的 探讨围手术期出血患者使用注射用尖吻蝮蛇血凝酶致结膜充血病例特征,为临床安全用药提供参考。方法 分析2例儿童患者术后使用注射用尖吻蝮蛇血凝酶止血时发生结膜充血病例,并对国内外相关文献进行归纳总结。结果 2例儿童使用尖吻蝮蛇血凝酶后立即发生结膜充血,时间上存在明显关联性,使用Naranjo's评价关联性为“可能”。2例停药及对症处理后均转归良好。结论 注射用尖吻蝮蛇血凝酶致结膜充血风险存在不可预知性,临床应引起重视,在特殊人群中用药前应充分评估安全性,并做好发生不良反应的应对抢救措施。

关键词: 尖吻蝮蛇血凝酶, 注射用, 儿童, 术后, 围手术期出血, 结膜充血, 药品不良反应

Abstract: Objective To investigate the clinical characteristics of conjunctival congestion caused by hemocoagulase agkistrodon for injection in patients with perioperative bleeding so as to provide a reference for safe clinical medication. Methods Two cases of conjunctival congestion that occurred after the postoperative use of hemocoagulase agkistrodon for injection for hemostasis were analyzed. Related literature was reviewed. Results Two pediatric patients experienced conjunctival congestion immediately after using hemocoagulase agkistrodon for injection. There was a significant temporal correlation. According to the Naranjo's Adverse Drug Reaction Probability Scale, the causality was assessed as possible. After quick symptomatic treatment, the patients recovered. Conclusion The risk of anaphylactic shock caused by hemagglutinin is unpredictable, which deserves the attention of medical staffs. Before prescribing the drug in high-risk populations, clinicians should take safety into consideration and take precautions.

Key words: Haemocoagulase Agkistrodon, Injection, Children, Postoperative, Perioperative Bleeding, Conjunctival Congestion, Adverse Drug Reaction

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