中国药物警戒 ›› 2025, Vol. 22 ›› Issue (10): 1183-1187.
DOI: 10.19803/j.1672-8629.20250248

• 综述 • 上一篇    下一篇

少弱精子症药物研究进展

唐田1,2, 谭天阳3, 刘柘君4, 白雪1,*   

  1. 1中国中医科学院医学实验中心,北京市中医药防治重大疾病基础研究重点实验室,北京 100700;
    2中国科学院北京基因组研究所,北京 100101;
    3中国中医科学院西苑医院康复医学科,北京 100091;
    4首都医科大学中医药学院,北京 100069
  • 收稿日期:2025-04-22 出版日期:2025-10-15 发布日期:2025-10-20
  • 通讯作者: * 白雪,女,博士,助理研究员,中药防治生殖系统疾病。E-mail: dr.baixue@hotmail.com
  • 作者简介:唐田,女,在读博士,中药对肠道菌群结构与功能作用的研究。
  • 基金资助:
    国家自然科学基金资助项目（82304767）; 中央级公益性科研院所基本科研业务费专项基金（JJPY2022021、ZZ15-YQ-055）; 中国中医科学院科技创新工程项目（CI2021B017）

Advances in Pharmacological Research on Oligoasthenozoospermia

TANG Tian1,2, TAN Tianyang3, LIU Zhejun4, BAI Xue1,*   

  1. 1Experimental Research Center, China Academy of Chinese Medical Sciences, Beijing Key Laboratory of Traditional Chinese Medicine Basic Research on Prevention and Treatment of Major Disease, Beijing 100700, China;
    2Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing 100101, China;
    3Rehabilitation Medicine Department, Xiyuan Hospital, Chinese Academy of Traditional Chinese Medicine, Beijing 100091, China;
    4School of Traditional Chinese Medicine, Capital Medical University, Beijing 100069, China
  • Received:2025-04-22 Online:2025-10-15 Published:2025-10-20

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摘要： 目的 聚焦近3~5年少弱精子症的药物研发核心方向,结合对应的动物模型研究成果,系统梳理药物作用机制与疗效进展,为临床防治少弱精子症的药物选择、机制深化及新药研发提供更具针对性的参考。方法 检索PubMed、中国知网等数据库,重点综述抗氧化应激药物、抗凋亡药物、代谢调节药物、靶向治疗药物、激素调节药物及中医药多靶点调控药物在少弱精子症模型中的研究进展,系统呈现各类药物的作用表现与研究数据。结果 抗氧化应激、抗凋亡、代谢调节、靶向治疗、激素调节药物及中医药多靶点调控药物均显示明确疗效,其中部分药物在改善氧化应激、线粒体功能障碍及凋亡失衡等核心病理问题上表现突出,对精子质量提升作用显著。结论 未来需深化药物作用机制研究,推动更多高效、安全的药物从基础研究迈向临床应用,为少弱精子症防治提供更有力的药物支持。

关键词: 少弱精子症, 抗氧化应激药物, 抗凋亡药物, 精子, 药物, 进展

Abstract: Objective To summarize the recent research advances in the mechanisms of action and therapeutic effects of drugs for oligoasthenospermia in combination with research findings from corresponding animal models in order to provide more targeted references for the selection of drugs, in-depth studies on mechanisms, and development of new drugs for prevention and treatment of oligoasthenospermia. Methods PubMed, CNKI, and other databases were searched particularly for literature on research progress in antioxidant stress drugs, anti-apoptosis drugs, metabolism-regulating drugs, targeted drugs, hormone-regulating drugs, and multi-target regulatory drugs of TCM using oligoasthenospermia models. The action of and research data on a range of drugs were elaborated. Results Antioxidant stress, anti-apoptosis, metabolism-regulating, targeted, hormone-regulating drugs, and multi-target regulatory drugs of TCM could all deliver distinct therapeutic effects. Some of these drugs were unusually effective at addressing critical pathological abnormalities such as oxidative stress, mitochondrial dysfunction, and apoptotic imbalance, thus significantly enhancing sperm quality. Conclusion More effort should be made to gain insights into the action mechanisms of drugs, promote the transition of more efficient and safe drugs from basic research to clinical applications in order to facilitate the prevention and treatment of oligoasthenospermia.

Key words: Oligoasthenospermia, Antioxidant Stress Drugs, Anti-Apoptosis Drugs, Sperm, Drug, Progress

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