中国药物警戒 ›› 2012, Vol. 9 ›› Issue (12): 737-739.

• 药械安全性研究 • 上一篇    下一篇

1447例口服抗糖尿病药品不良反应病例分析

赵珩1, 徐厚明2, 余江毅1   

  1. 1 江苏省中医院,江苏 南京210029；
    2 江苏省药品不良反应监测中心,江苏 南京210002
  • 收稿日期:2012-04-19 出版日期:2012-12-10 发布日期:2015-08-07
  • 作者简介:赵珩,女,在读硕士,中西医结合临床内分泌。

The Clinical Analysis on Adverse Drug Reaction of 1447 Cases Caused by Oral Antidiabetic Drugs

ZHAO Heng1, XU Hou-ming2, YU Jiang-yi1   

  1. 1 Jiangsu Province Hospital of Traditional Chinese Medicine, Jiangsu Nanjing 210029, China;
    2 Center for ADR Monitoring of Jiangsu, Jiangsu Nanjing 210002, China
  • Received:2012-04-19 Online:2012-12-10 Published:2015-08-07

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摘要： 目的分析口服抗糖尿病药品不良反应病例发生的特点和规律,为临床合理用药提供参考。方法从2004~2011年江苏省药品不良反应数据库中检索出口服抗糖尿病药品不良反应病例,采用描述性分析方法,对其发生时间、药品不良反应累及的系统-器官、怀疑药品种类等进行统计分析。结果共检索出符合条件的病例报告表1 447例,其中男性846例,女性601例,超过半数的病例发生在用药1天之内。双胍类、磺酰脲类二代、非磺酰脲类促胰岛素分泌剂列怀疑药品类别前3位。药品不良反应累及的系统-器官主要有胃肠系统损害、皮肤及其附件损害和中枢及外周神经系统损害。所有病例经恰当治疗后均治愈或好转。结论口服抗糖尿病药品引起的不良反应累及的系统-器官较多,临床上要严格掌握适应征,注意合理的联合用药,关注少见不良反应,确保用药安全。

关键词: 口服抗糖尿病药物, 药品不良反应, 临床分析

Abstract: ObjectiveThrough the clinical characteristics analysis of the adverse drug reaction cases caused by oral anti-diabetic drugs, provide reasonable advice for clinical use. MethodsTo retrieve the adverse drug reactions cases caused by oral antidiabetic drugs in the database of Center for ADR Monitoring of Jiangsu, and analyze the clinical manifestations time of onset, the system involved, types of drugs, etc by describing analysis. Results1447 cases were involved. 846 cases were male, 601 cases were female. More than half cases happened in one day. The types of the suspected drugs mostly were diguanides, sutfonylureasII and non-sulfonylurea drugs promoting insulin secretion. The systems involved of adverse drug reactions include gastrointestinal system, the skin and its appendages and the central and peripheral nervous system. All cases were healed or better after therapy. ConclusionStrictly master the indication of oral antidiabetic drugs, pay attention to the reasonable combination and rare adverse drug reactions, so as to ensure safe use.

Key words: oral antidiabetic drug, adverse drug reaction, clinical analysis