注射用替考拉宁致精神异常1例分析

doi:10.19803/j.1672-8629.2021.09.22

中国药物警戒 ›› 2021, Vol. 18 ›› Issue (9): 894-897.
DOI: 10.19803/j.1672-8629.2021.09.22

注射用替考拉宁致精神异常1例分析

沈秀秀¹, 周楠², 张维³, 张江红⁴, 李友佳^{5, *}

¹定边县人民医院,陕西榆林 718600;
²陕西省人民医院,陕西西安 710068;
³空军军医大学第一附属医院,陕西西安 710032;
⁴陆军第951医院,新疆库尔勒,841000;
⁵西安交通大学第二附属医院,陕西西安710004

收稿日期:2020-01-06 出版日期:2021-09-15 发布日期:2021-09-18
通讯作者: ^*李友佳,女,硕士,主管药师,临床药学。E-mail：lyjfanly@163.com
作者简介:沈秀秀,女,硕士,主管药师,临床药学。
基金资助:
国家自然科学基金资助项目（81703514）

Psychosis Induced by Teicoplanin: A Case Report

SHEN Xiuxiu¹, ZHOU Nan², ZHANG Wei³, ZHANG Jianghong⁴, LI Youjia^{5, *}

¹People's Hospital of Dingbian County, Yulin Shaanxi 718600, China;
²Shaanxi Provincial People's Hospital, Xi'an Shaanxi 710068, China;
³The First Affiliated Hospital of Air Force Medical University, Xi'an Shaanxi 710032, China;
⁴Army 951 Hospital, Korla Xinjiang 841000, China;
⁵The Second Hospital Affiliated to Xi'an Jiaotong University, Xi'an Shaanxi 710004, China

Received:2020-01-06 Online:2021-09-15 Published:2021-09-18

摘要/Abstract

摘要： 目的分析替考拉宁致精神异常1例,提示临床重视替考拉宁所致的药品不良反应。方法分析1例使用替考拉宁治疗耐甲氧西林金黄色葡萄球菌（MRSA）感染时出现精神异常患者的诊疗经过,通过文献分析,阐述替考拉宁诱发精神异常的主要原因。结果本例患者出现精神异常很可能是替考拉宁所致。结论替考拉宁的血药浓度在重症及合并低蛋白血症患者中变异性较大,治疗上应根据患者体重及白蛋白情况予以适宜的剂量,避免血药浓度过高出现相关不良反应。

关键词: 替考拉宁, 药品不良反应, 精神异常

Abstract: Objective To analyze one case of psychosis induced by teicoplanin in order to call clinical attention to adverse reactions caused by teicoplanin. Methods The process of diagnosis and treatment of a patient with mental disorder in the course of treatment of methicillin-resistant Staphylococcus aureus (MRSA) infection with teicoplanin was analyzed. Through literature review and analysis, the main causes of mental disorder induced by teicoplanin were described. Results This case of psychosis was likely induced by teicoplanin. Conclusion The concentration of teicoplanin among critically ill patients, especially those with hypoalbuminemia, is highly variable. An appropriate dose should be given on the basis of the patient’s weight and albumin so that the adverse reactions caused by high blood concentration could be prevented.

Key words: teicoplanin, adverse drug reaction, psychosis

中图分类号:

R994.11

沈秀秀, 周楠, 张维, 张江红, 李友佳. 注射用替考拉宁致精神异常1例分析[J]. 中国药物警戒, 2021, 18(9): 894-897.

SHEN Xiuxiu, ZHOU Nan, ZHANG Wei, ZHANG Jianghong, LI Youjia. Psychosis Induced by Teicoplanin: A Case Report[J]. Chinese Journal of Pharmacovigilance, 2021, 18(9): 894-897.

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https://zgywjj.magtechjournal.com/CN/Y2021/V18/I9/894

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注射用替考拉宁致精神异常1例分析

Psychosis Induced by Teicoplanin: A Case Report

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