中国药物警戒 ›› 2019, Vol. 16 ›› Issue (5): 289-292.

• 安全性评价与合理用药 • 上一篇    下一篇

376例注射用头孢曲松钠不良反应的文献分析

王芳1, 李永辉1,*, 郭瑞锋1, 邱志宏2, 刘欣欣1   

  1. 1 河北省药品监测评价中心,河北 石家庄 050090;
    2 河北省人民医院药学部,河北 石家庄 050051
  • 收稿日期:2018-05-15 修回日期:2019-06-11 出版日期:2019-05-20 发布日期:2019-06-11
  • 通讯作者: 李永辉,男,硕士,副主任药师,药品不良反应监测与评价。E-mail:hbfda157@126.com
  • 作者简介:王芳,女,硕士,主管药师,药品不良反应。

Literature Analysis of 376 Cases of Adverse Drug Reactions Induced by Ceftriaxone Sodium for Injection

WANG Fang1, LI Yonghui1,*, GUO Ruifeng1, QIU Zhihong2, LIU Xinxin1   

  1. 1 Center for Drug Monitoring and Evaluation of Hebei, Hebei Shijiazhuang 050090, China;
    2 Department of Pharmacy, Hebei People's Hospital, Hebei Shijiazhuang 050051, China
  • Received:2018-05-15 Revised:2019-06-11 Online:2019-05-20 Published:2019-06-11

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摘要： 目的 了解注射用头孢曲松钠致药品不良反应（ADR）的情况,探究其发生的规律和特点,为临床安全合理用药提供依据。方法 检索万方数据库、中国期刊全文数据库和维普数据库,对 2007年1月~2017年6月间国内公开发表的有关注射用头孢曲松钠376 例ADR病例文献报道进行回顾性分析。结果 ADR的发生与溶媒、联合用药、患者年龄、过敏史、饮酒史密切相关,应关注1分钟之内发生的严重ADR和迟发型ADR。过敏性休克、胆结石、泌尿系统结石在说明书中风险提示不足。超剂量用药是结石发生的风险因素。结论 临床应尽量选用氯化钠注射液做溶媒,单独使用头孢曲松钠,重点监测儿童用药,警惕迟发型不良反应,关注严重的、新的ADR,采取有效措施防治ADR。

关键词: 注射用头孢曲松钠, 药品不良反应, 文献分析

Abstract: Objective To understand the adverse reactions induced by ceftriaxone sodium for injection, and explore the regularity and characteristics of its occurrence, in order to provide a basis for safe and reasonable medication in clinic. Methods CNKI, WANFANG and VIP database were retrieved from January 2007 to June 2017, and 376 case reports of adverse drug reactions induced by ceftriaxone sodium were analyzed retrospectively. Results The incidence of ADR was related to solvent, combination, age, allergic history and alcohol-drinking history. Attention should be paid to the severe ADR that occured within 1 minute and delayed ADR. The risk warning of anaphylactic shock, gallstones and urinary calculi was insufficient in the drug instructions. Drug overdosage was a high risk factor for stones. Conclusion We should try to use sodium chloride as solvent, infuse alone, monitor children medication, be alert to the delayed ADR, pay attention to serious and new ADR, and take effective measures to prevent ADR.

Key words: ceftriaxone sodium for injection, adverse drug reaction, literature review

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