中国药物警戒 ›› 2018, Vol. 15 ›› Issue (4): 197-200.

• 基础与临床研究 • 上一篇    下一篇

4-甲基环十五烷酮对心肌缺血再灌注损伤保护作用

王永玲1, 薛云2, 戴晓莉2, 马玉奎2,*   

  1. 1山东省临朐县人民医院,山东 临朐,262600;
    2山东省药学科学院,山东 济南 250100
  • 收稿日期:2018-05-29 修回日期:2018-05-29 出版日期:2018-04-20 发布日期:2018-05-29
  • 通讯作者: 马玉奎,男,博士,主任药师,新药药理毒理评价。 E-mail：mayk@sdapsglp.cn
  • 作者简介:王永玲,女,本科, 主管药师,临床药学。
  • 基金资助:
    中央引导地方科技发展专项（CXLC161906）:创新药物临床前评价公共服务平台

Protective Effects of 4-Methylcyclopentadecanone on Myocardial Ischemia/Reperfusion Injury

WANG Yong-ling1, XUE Yun2, DAI Xiao-li2, MA Yu-kui2,*   

  1. 1People's Hospital of Linqu County, Shandong Linqu 262600, China;
    2Shandong Academy of Chinese Medicine, Shandong Jinan 250100, China
  • Received:2018-05-29 Revised:2018-05-29 Online:2018-04-20 Published:2018-05-29

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摘要： 目的 探讨4 -甲基环十五烷酮（4-MCPC）对心肌缺血再灌注损伤的保护作用及其作用机制。方法 采用结扎左冠脉前降支30 min后再灌注2 h制备心肌缺血再灌注损伤（MI/R）大鼠模型,采用麝香酮为对照,以心肌梗死面积、血清中CK、LDH水平和心肌组织中MPO活性以及TNF-α、IL-1β含量为评价指标,全面考察4-MCPC对模型大鼠心肌缺血再灌损伤的保护作用及其作用机制。结果 与模型组比较,4-MCPC 20、10 mg·kg-1组大鼠心肌梗死面积明显减少;血清中CK、LDH水平降低;心肌组织中MPO活性明显降低;TNF-α和IL-1β含量明显减少。结论 4-MCPC对MI/R模型大鼠心肌缺血再灌注损伤具有一定的保护作用。

关键词: 4-甲基环十五烷酮, 缺血再灌注损伤, 炎症反应, 大鼠

Abstract: Objective To investigate the effects and mechanism of 4-methylcyclopentadecanone(4-MCPC) on myocardial ischemia/reperfusion(MI/R) injury on rat model. Methods MI/R rat model was established by coronary artery ligation for 30 min followed with 2 h reperfusion. Muscone was selected as control. Myocardial ischemic infarction was calculated and the level of CK, LDH in serum, the activity of MPO and the content of TNF-α, IL-1β in heart homogenate were detected to evaluate the effects of 4-MCPC on MI/R rats. Results Compared with model group, the myocardial ischemic infarction, CK, LDH level in serum, the activity of MPO and the content of TNF-α, IL-1β in heart homogenate were dramatically decreased in 4-MCPC(20, 10 mg·kg-1) group rats. Conclusion 4-MCPC displayed certain protective effects on MI/R rat model.

Key words: 4-MCPC, ischemia/reperfusion injury, inflammation reaction, rat

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