中国药物警戒 ›› 2018, Vol. 15 ›› Issue (2): 78-82.

• 利巴韦林临床使用调查分析专栏 • 上一篇    下一篇

鄞州区门诊利巴韦林注射剂18至44岁育龄使用者用药情况分析

李海龙1, 赵厚宇1, 林鸿波3, 刘翠丽2, 沈鹏3, 詹思延1,*   

  1. 1 北京大学公共卫生学院流行病与卫生统计系，北京 100191;
    2 国家食品药品监督管理局药品评价中心，北京 100045;
    3 宁波市鄞州区疾病预防控制中心，浙江 宁波 315100
  • 收稿日期:2017-12-20 修回日期:2018-03-28 出版日期:2018-02-20 发布日期:2018-03-28
  • 通讯作者: 詹思延，女，教授?博导，药物流行病学。E-mail: siyan-zhan@bjmu.edu.cn
  • 作者简介:李海龙，男，在读博士，药物流行病学。

Utilization of Ribavirin Injection Among Reproductive Population Aged 18 to 44 Years Old Based on Yinzhou District Healthcare Database

LI Hai-long1, ZHAO Hou-yu1, LIN Hong-bo3, LIU Cui-li2, SHEN Peng3, ZHAN Si-yan1,*   

  1. 1 Department of Epidemiology and Bio-statistics, School of Public Health, Peking University, Beijing 100191, China;
    2 Center for Drug Revaluation, CFDA, Beijing 100045, China;
    3 Yinzhou District Center for Disease Control and Prevention, Zhejiang Ningbo 315100, China
  • Received:2017-12-20 Revised:2018-03-28 Online:2018-02-20 Published:2018-03-28

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摘要： 目的 分析鄞州区医疗机构门诊利巴韦林注射剂育龄使用者情况。方法 从鄞州区医疗卫生信息数据库6 896万余条门诊记录中提取2010年至2016年期间，利巴韦林注射剂处方中18~44岁使用者的处方数据，包含206 511例患者的363 882张处方，分析育龄人群利巴韦林的用药情况。结果 研究期间，鄞州区18~44岁的就诊总人数为3 665 082例，总处方数为20 508 923张。其中利巴韦林注射剂使用者人数占总人数1.77%，处方次数占总处方数5.71%。符合说明书要求的次剂量处方约占总处方数的85.59%，日剂量处方约占总处方的99.33%。妊娠诊断记录前后6个月有利巴韦林注射剂处方的患者有617例。结论 利巴韦林注射剂处方存在不合理，医务人员应规范处方适应证和使用剂量，尤其在为育龄期妇女处方时应常规询问末次月经，同时提示患者避免在用药期间和停药后6个月内怀孕。

关键词: 利巴韦林, 妊娠, 药物利用, 合理用药

Abstract: Objective To describe the clinical utilization of ribavirin injection among reproductive population in Yinzhou district, Ningbo city. Methods A descriptive analysis of the clinical utilization of ribavirin injection among reproductive population aged 18 to 44 in 3 general hospitals and 24 community health centers from 2010 to 2016 was conducted by using Yinzhou healthcare information database. Results During the study period, it was found that there were 363 882 outpatients' prescriptions of ribavirin injection and 206 511 ribavirin users. According to the instructions, the number of ribavirin injections prescription which met the requirement of each dose and daily dose accounted for 85.59% and 90.33% of the total number of ribavirin injection prescriptions respectively. Among our study population, there were 617 patients who had a diagnosis of pregnancy within 6 months of ribavirin prescription. Conclusion The results indicated that there were large amount of irrational prescriptions of ribavirin. Clinicians should adhere to the indication of ribavirin injection and requirement of dose, and be cautious when prescript to reproductive patients.

Key words: ribavirin, pregnancy, drug utilization, rational drug use

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