92例奥曲肽不良反应文献分析

摘要/Abstract

摘要： 目的探究奥曲肽致不良反应一般规律及特点,为奥曲肽临床安全合理使用提供参考。方法以“奥曲肽”、“善得定”、“善宁”、“不良反应”、“致”为检索词,检索中国期刊网全文数据库、维普中文期刊全文数据库、万方数据库,按纳入与排除标准筛选34篇文献,通过文献提取病例进行归纳分析。结果不良反应多发生于中青年患者,原患疾病主要为胰腺炎,不良反应多发于用药后24 h内,累及系统-器官损害主要为心血管系统和全身性损害等,不良反应以心律失常、心悸等最为常见。结论重视奥曲肽引起的不良反应,加强临床用药指导,确保用药安全。

关键词: 奥曲肽, 不良反应, 文献分析

Abstract: Objective Through investigating the characteristics and mechanism of adverse reactions induced by octreotide, to find its risk factors and provide technical support for safe and rational use of drugs in clinic. Methods Using "octreotide", "Sandostain", "Shanning", "adverse reaction"and "to"as key words to search and retrieve articles in the CNKI database, VIP Chinese full-text database and Wanfang database. 34 references which met the inclusion criteria were extracted and analyzed. Results Most of the reactions occurred in young and middle-aged patients. The major illness was pancreatitis. ADRs occurred more frequently within 24 h. Systems and organs mainly involved in adverse reactions were cardiovascular system damage, systemic lesion, etc. Arrhythmia and palpitation are the most commonly reported adverse reactions. Conclusion It is important to pay attention to the adverse reactions caused by octreotide, strengthen clinical rational use of drugs, in order to ensure the safe drug use in clinic.

Key words: octreotide, adverse drug reactions, literature review

中图分类号:

R994.11

谢文静. 92例奥曲肽不良反应文献分析[J]. 中国药物警戒, 2017, 14(9): 551-554.

XIE Wen-jing. Literature Review on 92 Cases of Adverse Reactions Induced by Octreotide[J]. Chinese Journal of Pharmacovigilance, 2017, 14(9): 551-554.

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