中国药物警戒 ›› 2017, Vol. 14 ›› Issue (5): 304-308.

• 安全性评价与合理用药 • 上一篇    下一篇

433例药源性肺部疾病文献分析

马莉, 韩小年, 黄婧, 彭莉蓉*   

  1. 西安市中心医院药剂科临床药学室,陕西 西安710003
  • 收稿日期:2017-07-12 修回日期:2017-07-12 出版日期:2017-05-20 发布日期:2017-07-12
  • 通讯作者: 彭莉蓉,女,硕士,主任药师,临床药学与合理用药。E-mail：13572006077@126.com

Literature Analysis of 433 Cases of Drug-induced Pulmonary Diseases

MA Li, HAN Xiao-nian, HUANG Jing, PENG Li-rong*   

  1. Department. of Pharmacy, Xi’an Central Hospital, Shanxi Xi’an 710003, China
  • Received:2017-07-12 Revised:2017-07-12 Online:2017-05-20 Published:2017-07-12

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摘要： 目的 探讨引起药源性肺部疾病的药品种类及其临床表现特点,为临床合理用药提供依据。方法 检索1979~2015年国内期刊公开报道的药源性肺部疾病文献并进行统计分析。结果 检索出相关文献227篇,共计病例433例,主要涉及心血管药物、抗肿瘤药物、非甾体抗炎类药物、抗生素及中药注射剂等。主要表现为哮喘、间质性肺炎、肺水肿、肺间质纤维化等。大部分病例停药及对症治疗后好转,其中53例患者死亡。结论 多种药物可引起药源性肺部疾病,临床需提高警惕,以降低不良反应的发生。

关键词: 药源性肺部疾病, 不良反应, 安全用药

Abstract: Objective To investigate the drugs leading to drug-induced pulmonary diseases and discuss their clinical characteristics, so as to provide reference for rational drug use in the clinic. Methods Literatures of drug-induced pulmonary diseases publicly reported in domestic medical journals from 1979 to 2015 were collected and analyzed statistically. Results A total of 227 relevant articles were identified, which reported 433 cases of drug-induced pulmonary diseases, involving cardiovascular drugs, anticancer drugs, non-steroidal anti-inflammatory drugs, anti-microbial agents and traditional Chinese medicine injections. The main syndromes were asthma, interstitial pneumonia, drug-induced pulmonary edema, pulmonary fibrosis,etc. Most cases improved after drug withdrawal and symptomatic treatment, but 53 patients died. Conclusion A variety of drugs can induce drug-related lung damages. It is necessary to be vigilant, so as to reduce the incidence of adverse reactions.

Key words: drug-induced pulmonary diseases, adverse reaction, safe drug use

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