中国药物警戒 ›› 2010, Vol. 7 ›› Issue (11): 646-648.

• 半夏毒性影响因素研究 • 上一篇    下一篇

半夏不同组分小鼠急性毒性的比较研究

陆永辉1 王丽2 黄幼异2 朱兰兰3 吕丽莉1 孙蓉1   

  1. 1.山东省中医药研究院,山东济南250014；
    2.山东中医药大学,山东济南250355；
    3.天津中医药大学,天津300193
  • 收稿日期:2010-08-20 修回日期:2016-03-09 出版日期:2010-11-08 发布日期:2016-03-09
  • 通讯作者: 孙蓉,女,研究员,硕士生导师,中药药理与毒理。E-mail：sunrong107@163.com
  • 作者简介:陆永辉,男,本科,医药工程与数学药理。
  • 基金资助:
    国家重点基础研究发展计划（973）中医基础理论专项资助项目（2009CB522802）；山东省科技平台建设项目（2008GG2NS02021）；山东省中医局科技发展计划课题（2007-119）

Comparative Study on Acute Toxicity of Different Components of Rhizoma Pinelliae in Mice

LU Yong-hui1 ,WANG Li2 ,HUANG You-yi2, ZHU Lan-lan3 ,LV Li-li1, SUN Rong1   

  1. 1.Shandong Research Academy of TCM, Shandong Jinan 250014, China;
    2.Shandong University of Traditional Chinese Medicine, Shandong Jinan 250355,China, 3Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China
  • Received:2010-08-20 Revised:2016-03-09 Online:2010-11-08 Published:2016-03-09

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摘要： 目的 对半夏全组分、水提组分和醇提组分进行小鼠急性毒性比较研究,以观察、评价半夏药材的急性毒性,为临床安全、合理用药提供依据。方法 制备半夏全组分、水提组分和醇提组分样品,采用经典的小鼠急性毒性实验方法分别测定半夏全组分、水提组分的最大给药量和醇提组分的最大耐受量。结果 半夏全组分的最大给药量（MLD）为34.8 g/kg,水提组分的最大给药量（MLD）为300.0g/kg,醇提组分的最大耐受量（MTD）为99.2g/kg,分别相当于临床70kg 人每公斤体重日用量的270.7 倍、2 333.3 倍和771.6 倍。结论 半夏药材具有一定毒性,与药典、文献记载及临床应用相符。半夏醇提组分毒性大于水提组分及全组分,后两者基本安全、低毒。

关键词: 半夏, 不同组分, 小鼠, 急性毒性

Abstract: Objective Mice's acute toxicity of different components of Rhizoma Pinelliae was compared, to make an observation and evaluation of acute toxicity of Rhizoma Pinelliae in order to providea basis for safe and reasonable medication in clinic. Methods Preparing the all components,water extraction components and alcohol extraction components,then ig. all-components,water extract and alcohol extract of Rhizoma Pinelliae to mice and the MLD, MLD, MTD were tested respectively by the classic Methods of acute toxicity. Results The MLD of all-components is 34.8g/kg;the MLD of water extract is 300.0g/kg and the MTD of alcohol extract is 99.2g/kg,which is respectively equal to 270.7 times,2 333.3 times and 771.6 times of 70kg people's daily dried medicinal herb expenses. Conclusion Rhizoma Pinelliae has certain toxicity,which is consistent with the pharmacopoeia,references and clinical application.The mice's acute toxicity of different components of Rhizoma Pinelliae is alcohol extraction components >water extraction components and all-components, while the last two components are atoxic on the whole.

Key words: Rhizoma Pinelliae , different components, mice, acute toxicity

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