中国药物警戒 ›› 2010, Vol. 7 ›› Issue (12): 748-750.

• 药品不良反应监测 • 上一篇    下一篇

249例β-内酰胺类抗菌药物的不良反应分析

曲彩红,苏向阳,黎小妍,张平   

  1. 广东中山大学附属第三医院,广东广州 510630
  • 收稿日期:2010-01-28 修回日期:2016-03-09 出版日期:2010-12-08 发布日期:2016-03-09
  • 作者简介:曲彩红,女,副主任药师,药品不良反应监测。

Analysis for 249 Cases of Adverse Drug Reaction of β-lactams Antibiotics and its Preventive Measure

QU Cai-hong ,SU Xiang-yang ,LI Xiao-yan ,ZHANG Ping   

  1. The Third Affiliated Hospital of Sun Yat-sen University, Guangdong, Guangzhou 510630, China
  • Received:2010-01-28 Revised:2016-03-09 Online:2010-12-08 Published:2016-03-09

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摘要： 目的 考察β-内酰胺类抗菌药物不良反应的流行病学状况并探讨其预防措施。方法以我院2006-2009 年上报告国家药品不良反应监测中心的249 例β- 内酰胺类抗菌药物的不良反应为考察对象,按照药品不良反应类型、药理作用、年龄、性别、剂型进行分类、整理、归纳和总结。结果-内酰胺类累及系统- 器官涉及皮肤及其附件、中枢神经系统、消化系统、血液系统、泌尿系统等。其中皮肤及其附件损害、中枢神经系统、胃肠道反应容易发现,消化系统、血液系统、泌尿系统的反应具有隐匿性。结论用药前了解既往过敏史,尽可能地减少联合用药,选择合理地给药方法,按照说明书剂量给药是防止抗菌药物不良反应发生的根本途径。

关键词: β-内酰胺类抗菌药物, 药品不良反应, 合理用药

Abstract: Objective To investigate the epidemiology of adverse drug reaction(ADR) of β-lactams antibiotics and its preventive measure. Methods We classified and analyzed 249 cases of adverse drug reaction of β-lactams antibiotics which is reported to National center for ADR Monitoring during 2006～2009, according to the type of adverse drug reaction、pharmacological action, age, sex, form of medication. Results adverse drug reaction of β-lactams involved in skin and its appendix、central nervous system、digestion system、hematological system、urinary system and so on. Among them skin and its appendix、central nervous system and gastrointestinal reactions are easy to acquire, others are obscure and difficult to find. Conclusion To comprehend the past hypersensitive history before administration, decrease drug combination, select rational administration, and administrate according to instruction dosage is the fundamental path to prevent ADR.

Key words: β-lactams antibiotics, adverse drug reaction, rational administration

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