[1] 周光德.药物性肝损伤100例临床病理分析[J].中华肝脏病,2007, 15(3):212. [2] HoodL,Heath JR,Phelps ME,et al. Systems biology and new technologiesenable predictive and preventative medi cine [J]. Science,2004,306(5696):640-643. [3] PujolA,Mosca1R,Farre'sJ,et al. Unveiling the role of network and systems biology in drug discovery [J].Trends Pharmacol Sci,2010,31(3):115-123. [4] 陈勇.应用基因表达谱芯片研究黄药子对小鼠肝脏的毒性机制[J].分子细胞生物学报,2006,39:568-571. [5] Kiela P R, Midura A J, Kuscuoglu N, et al. Effects of Boswellia serrata in mouse models of chemically induced colitis [J] . AmJ Physio Gastroint2est Liver Physiol, 2005,288(4):798. [6] YAMAMOTO T,KIKKAWA R,YAMADA H, et al. Investigation of proteomic biomarkers in vivo hepatotoxicity study of rat liver: toxicity differentiation in hepatotoxicants[J].J Toxicol Sci,2006,31(1):49-60. [7] FELLA K,GLBCKMANN M,HELLMANN J, et al. Use of twodimensional gel electrophoresis in predictive toxicology: identification of potential early protein biomarkers in chemically induced hepatocarcinogenesis[J]. Proteomics,2005,5(7),1914-1927. [8] ANDERSON NL, TAYLOR J. Simultaneous measurement of hundreds of liver proteins: application in assessment of liver function[J].Toxicol Pathol,1996,24 (1):72-76. [9] ZGODA V,TIKHONOVA O,V IGL INSKAYA A, et al. Proteomic profiles of induced hepatotoxicity at the subcellular level [J].Proteomics,2006,6(16):4662-4670. [10] 刘瑞媛,叶华,谢婷,等.代谢组学及其在药物毒性评价中的应用[J].生命的化学,2010, 30(50):774-777. [11] 徐国良,马晓雪,张启云,等.代谢组学评价黄连对大鼠药理作用的初步研究[J].中国中药杂技,2009,34(14):1845-1847. [12] 王全军,颜贤忠,吴纯启,等.Z24 经口染毒大鼠尿液的核磁共振谱代谢组学研究[J].中国药理学与毒理学杂志,18:460-465. [13] Mazzanti G, Battinelli L, Daniele C, et al.Newcase of acute hepatitis following the consumption of Shou Wu Pian, a Chinese Herbal product derived from Polygonum multiflorum[J]. Ann Intern Med,2004,140: W30. [14] Itoh S, Marutani K, Nishijima T, et al. Liver injuries induced by herbal medicine, Syo-saiko-to (xiao-chai-hu-tang)[J]. Digest Dis Sci,1995,40: 1845-1848. [15] Vanderperren B, Rizzo M, Angenot L, et al.Acute liver failure with renal impairment related to the abuse of senna anthraquinone glycosides[J]. Ann Pharmacother,2005, 39: 1353-1357. [16] YuenMF, TamS, Fung J, et al. Traditional Chinesemedicine causing hepatotoxicity in patients with chronic hepatitis B infection: a 1-year prospective study [J].Aliment Pharmacol Ther,2006,24: 1179-1186. [17] Chang-Hsing Lee, Jung-DerWang, Pau-Chung Chen1.Risk of Liver Injury Associated with Chinese Herbal Products Containing Radix bupleuri in 639,779 Patients with Hepatitis B Virus Infection[J].PLoSONE,2011,6(1),1-5. |