热毒宁注射液药理作用、临床应用及不良反应

中国药物警戒 ›› 2013, Vol. 10 ›› Issue (4): 215-218.

热毒宁注射液药理作用、临床应用及不良反应

罗先才

湖北省麻城市人民医院,湖北麻城 438300

收稿日期:2013-02-26 修回日期:2016-03-09 出版日期:2013-04-08 发布日期:2016-03-09
作者简介:罗先才,男,大专,主管药师,临床药学。

Pharmacological Effect, Clinical Application and Adverse Reaction of Reduning Injection

LUO Xian-cai

Hubei People's Hospital of Macheng City, Hubei Macheng 438300, China

Received:2013-02-26 Revised:2016-03-09 Online:2013-04-08 Published:2016-03-09

摘要/Abstract

摘要： 目的总结热毒宁注射液的药理作用、临床应用及不良反应,为临床安全有效合理应用提供±据。方法对国内外近期公开报道的热毒宁注射液药理作用、临床应用及不良反应进行整理、总结、分析。结果热毒宁注射液具有较强的抗病毒和抗菌作用,能有效增加机体免疫功能,提高抗病能力。临床广泛用于呼吸道感染,疗效确切,也有一些将其用于病毒性腹泻、带状疱疹、小儿疱疹性咽峡炎等疾病的超说明书用药的报道。其不良反应报道有过敏反应、过敏性休克、皮肤及附件损害、血尿、急性喉头性水肿等。结论热毒宁注射液对呼吸道感染性疾病疗效肯定,但临床上有不符合“中药注射剂临床使用基本原则”的报道。临床医生应严格按说明书中的功能主治,合理使用热毒宁注射液,完善不良反应处理措施,提高其用药安全性。

关键词: 热毒宁注射液, 药理作用, 临床应用, 不良反应

Abstract: Objective By reviewing the pharmacological effect, clinical application and adverse reactions of Reduning injection, to provide the basis for safe, effective and reasonable clinical application. Methods The related references in recent years at home and abroad about the pharmacological effect, clinical application and adverse reactions of Reduning injection were collected, summarized and analyzed. Results Reduning injection had obvious antiviral and antibacterial effect, and could effectively increase the body's immune function and improve the disease resistance. Reduning injection has been widely used in respiratory infection and is effective. There were some off-label use reports in which it was used in viral diarrhea, herpes zoster, infantile herpangina, ect. The adverse reactions included allergic reaction, anaphylactic shock, skin and accessories damage, hematuria, and acute laryngeal edema, etc. Conclusion Reduning injection had definitely curative effect on respiratory infection, but there were some off-label clinical use reports. Clinical doctors should strictly and reasonably use reduning injection according to its indications, perfect the countermeasures of adverse reactions in order to improve the safety of drugs.

Key words: Reduning injection, pharmacological effect, clinical application, adverse reactions

中图分类号:

R286

罗先才. 热毒宁注射液药理作用、临床应用及不良反应[J]. 中国药物警戒, 2013, 10(4): 215-218.

LUO Xian-cai. Pharmacological Effect, Clinical Application and Adverse Reaction of Reduning Injection [J]. Chinese Journal of Pharmacovigilance, 2013, 10(4): 215-218.

参考文献

[1] 吴叶宽,李隆云,钟国跃.青蒿的研究概况[J].重庆中草药研究,2004,19（2）：58-59.
[2] 武晓红,田智勇,王焕.金银花的研究新进展[J].时珍国医国药. 2005,16(12)：130-133.
[3]杨方花.栀子的药理作用概述[J].泰山卫生,2005,29(2)：17.
[4] 冯旰珠,周锋,黄茂,等.热毒宁对流感病毒FM1的抑制作用[J].中国新药与临床杂志,2007,26(9)：663-667.
[5] 冯旰珠,周锋,黄茂,等.热毒宁抗呼吸道合胞病毒（RSV,Long株）作用体外实验研究[J].南京医科大学学报,2007,27(9)：1009-1012.
[6] 冯旰珠,周锋,黄茂,等.热毒宁注射液对腺病毒-3的体外抑制作用[J].中国新药与临床杂志,2007,26(8)：573-577.
[7] 冯旰珠,周锋,黄茂,等.热毒宁注射液对人鼻病毒（N36）的体外抑制作用[J].中国药科大学学报,2008,39(3)：262-266.
[8] 余俭.抗菌抗病毒新药-热毒宁注射液[J].中南医药,2010,8(7)：548-550.
[9] 陈新谦,金有%,汤光.新编药物学[M].第16版.北京：人民卫生出版社,2007：134.
[10]陈灵红.热毒宁注射液治疗小儿急性上呼吸道感染102例[J].浙江中西医结合杂志,2008,18（6）：391.
[11]赵罗忠,张元明,王爱珍,等.热毒宁注射液治疗上呼吸道感染 78例疗效观察[J].辽宁医学杂志,2010,24（3）：148-149.
[12]杜悦,吴玉斌,王玲,等.热毒宁注射液治疗儿童上呼吸道感染的疗效和安全性观察[J].实用药物与临床,2007,10（6）：346-347.
[13]徐理,于烨华,张国兵.热毒宁注射液联合奥司他韦治疗流行性感冒疑似患者疗效观察[J].现代中西医结合杂志,2010,19(30):3264.
[14]张焕民.热毒宁注射液治疗流行性感冒60例[J].中国社区医师,2007,9(19):154-155.
[15]李建业,张彦伦,魏璐璐,等.热毒宁注射液治疗毛细支气管炎临床分析[J].中国实用医药,2010,5（5）：13.
[16]俞晓铭.热毒宁注射液联合头孢呋辛治疗老年慢性支气管炎118例[J].中国中医急症,2010,l9(2)：305.
[17]王辉.热毒宁注射液雾化吸入治疗急性支气管炎的临床观察[J].中国现代药物应用,2010,4(15)：140-141.
[18]张修刚,韩在彬,韩军学,等.热毒宁注射液治疗小儿病毒性肺炎60例疗效观察[J].齐鲁药事,2008,27（3）：178-179.