中国药物警戒 ›› 2010, Vol. 7 ›› Issue (8): 449-450.

• 基础研究 •    下一篇

离子色谱法测定氨基葡萄糖枸橼酸钙分散片的含量

黄鹏1, 张秀真2, 田德祥2, 冯传平3   

  1. 1安徽中医学院药学院,安徽省现代中药重点实验室,安徽 合肥 230031;
    2安徽大学化学化工学院,安徽 合肥 230001;
    3湖南中医药高等专科学校药学系,湖南 株洲 412012
  • 收稿日期:2016-02-22 修回日期:2016-02-22 出版日期:2010-08-08 发布日期:2016-02-22
  • 作者简介:黄鹏,男,讲师,药物化学教学及科研。

Ion Chromatography Determination of Glucosamine Calcium Citrate Dispersible Tablets

HUANG Peng1, ZHANG Xiu-Zhen2, TIAN De-xiang2, FENG Chuan-Ping3   

  1. 1Anhui University of Traditional Chinese Medicine, Anhui Key Laboratory of Modernized Chinese Material, Anhui Hefei 230031, China;
    2College of Chemistry and Chemical Engineering, Anhui University, Anhui Hefei 230001, China;
    3Department of Pharmacy, Hunan College of Traditional Chinese Medicine, Hunan Zhuzhou 412012, China
  • Received:2016-02-22 Revised:2016-02-22 Online:2010-08-08 Published:2016-02-22

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摘要： 目的 建立离子色谱法测定氨基葡萄糖枸橼酸钙分散片中盐酸氨基葡萄糖的含量。方法 色谱条件：CarboPacTM PA200 3 mm×250 mm（带 CarboPacTMPA200 3 mm×50 mm 保护柱）;积分脉冲安培检测器（采用四电位波形）;流动相：0.2mol/L NaOH,流速0.5mL/min;进样体积：25 L;柱温30℃。结果 盐酸氨基葡萄糖的线性范围0.01~0.2 mg/L（r =0.999 5）,回收率为 99.5%。结论 离子色谱法准确、简便、快速,可用于氨基葡萄糖枸橼酸钙分散片的含量测定。

关键词: 离子色谱法, 氨基葡萄糖枸橼酸钙分散片, 含量

Abstract: Objective To establish an assay method of determination for Glucosamine hydrochloride of Glucosamine Calcium Citrate Dispersible Tablets by ion chromatography(IC). Methods The assay was performed on CarboPacTM PA200 3mm×250mm(with CarboPacTM PA200 3mm×50mm protective column); mobile phase:0.2mol/L NaOH,The flow rate was 0.5mL/min; the column temperaturetemprature 30℃. Results The line ranges of Glucosamine hydro-chloride as partate was 0.01~0.2 mg/L(r=0.9995),The average recoveries of Glucosamine hydrochloride were 99.5%. Conclusion The method is proved to be rapid, accurate, and convenient,and provided a reliable way for evaluating the quality of Glucosamine hydrochloride as Glucosamine Calcium Citrate Dispersible Tablets.

Key words: ion chromatography, glucosamine calcium citrate dispersible tablets, determination

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