中国药物警戒 ›› 2014, Vol. 11 ›› Issue (12): 757-759.

• 药械安全性研究 • 上一篇    下一篇

医用一次性聚氯乙烯连接管对药物吸附性的试验研究

周进2, 程云章1 *, 罗文香1   

  1. 1上海理工大学医疗器械与食品学院,上海 200093;
    2江苏省食品药品监督管理局,江苏 扬州 225261
  • 收稿日期:2014-03-31 修回日期:2016-02-03 出版日期:2014-12-08 发布日期:2016-03-02
  • 通讯作者: 程云章,男,教授,医疗器械风险管理。
  • 作者简介:周进,男,硕士,医疗器械风险管理。

Experimental Study on the Drug Absorptivity of Medical Disposable PVC Connection Tube

ZHOU Jin2, CHENG Yun-zhang1, *, LUO Wen-xiang1   

  1. 1School of Medical and Food Engineering, University of Shanghai for Science and Technology, Shanghai 200093, China; 2Jiangsu Food and Drug Administration, Jiangsu Yangzhou 225261, China
  • Received:2014-03-31 Revised:2016-02-03 Online:2014-12-08 Published:2016-03-02

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摘要： 目的研究医用一次性聚氯乙烯（PVC）连接管对多种药物的吸附性,为临床一次性连接管的选择提供参考。方法将硝酸甘油、尼莫地平、单硝酸异山梨酯等6种药物分别配成临床输注浓度,通过吸光度试验测试流经连接管前后药物浓度,计算得出6种药物不同时间段的吸附率。结果医用一次性PVC连接管对不同药物的吸附性不同,连接管对尼莫地平具有很强的吸附性,最高可达29.6%。结论PVC连接管的吸附性与药液的酸碱性没有明显关系;PVC连接管对部分药物具有极强的吸附作用,应引起临床使用的高度重视。

关键词: PVC连接管, 吸光度, 药物吸附

Abstract: ObjectiveTo investigate the absorptivity of medical disposable PVC connection tube to various drugs, as a reference for clinical choice of disposable PVC connection tube. MethodsSolution of 6 kinds of drugs, such as nitroglycerin, nimodipine and isosorbide mononitrate,were prepared separately as per actual concentration needed by the clinic. Drug concentrations before and after through the connection tube were measured by absorbance experiment and eventually calculated absorption rate of 6 kinds of drugs in different time. ResultsThe various drugs have different absorption rate and nimodipine gets a rather high value which can be up to 29.6%. ConclusionThe absorptivity of PVC connection tube has little relation to acid-base property. They have marked absorptivity to part of drugs. High attention from the clinic should be paid to the difference.

Key words: PVC connection tube, absorbance, drug absorptivity

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