中国药物警戒 ›› 2026, Vol. 23 ›› Issue (7): 814-816.
DOI: 10.19803/j.1672-8629.20250425

• 安全与合理用药 • 上一篇    下一篇

注射用哌拉西林钠他唑巴坦钠致抽搐伴呼吸困难1例分析

刘丽娜, 张凤琴, 杨帆, 刘渊*   

  1. 兰州市肺科医院药剂科,甘肃 兰州 730046
  • 收稿日期:2025-06-27 出版日期:2026-07-15 发布日期:2026-07-16
  • 通讯作者: *刘渊,男,硕士,副主任药师,医院药学。E-mail: 279099363@qq.com
  • 作者简介:刘丽娜,女,硕士,主管药师,临床合理用药与药物警戒。
  • 基金资助:
    兰州市卫生健康行业科研项目（A2024034）; 兰州市科技发展指导性计划项目（2020-ZD-153）

One case of convulsions and dyspnea caused by piperacillin sodium and tazobactam sodium for injection

Liu Lina, Zhang Fengqin, Yang Fan, Liu Yuan*   

  1. Department of Pharmacy, Lanzhou Pulmonary Hospital, Lanzhou Gansu 730046, China
  • Received:2025-06-27 Online:2026-07-15 Published:2026-07-16

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摘要： 目的 探讨注射用哌拉西林钠他唑巴坦钠致抽搐伴呼吸困难的病例,为临床安全用药提供参考。方法 对1例慢性阻塞性肺疾病急性加重患者发生抽搐伴呼吸困难的病例进行分析,结合文献梳理其发生机制和治疗方法。结果 经关联性分析,该患者出现抽搐伴呼吸困难不良反应与注射用哌拉西林钠他唑巴坦钠关联性为“肯定”,患者经停药并给予注射用头孢哌酮钠舒巴坦钠治疗后好转。结论 注射用哌拉西林钠他唑巴坦钠可能通过拮抗γ-氨基丁酸受体诱发惊厥,多见于肾功能不全或给药过量时发生,临床治疗中需注意此类神经系统不良事件,保障患者用药安全。

关键词: 注射用哌拉西林钠他唑巴坦钠, 慢性阻塞性肺疾病, 抽搐, 呼吸困难, γ-氨基丁酸受体, 药品不良反应

Abstract: Objective To analyze the cause of convulsions accompanied by dyspnea induced by piperacillin sodium and tazobactam sodium for injection so as to provide a reference for safe clinical medication. Methods One case of serious adverse reactions in an AECOPD patient during treatment was retrospectively analyzed, and clinical manifestations and treatment regimens were summarized. Results Correlation analysis suggested that the adverse reaction of convulsions accompanied by dyspnea in this patient was definitively associated with the piperacillin sodium and tazobactam sodium injection. After discontinuation of piperacillin sodium and tazobactam sodium injection and effective treatment with cefoperazone sodium and sulbactam sodium injection, the patient’s symptoms were relieved. Conclusion Piperacillin sodium and tazobactam sodium injection may induce convulsions by antagonizing the γ-aminobutyric acid (GABA) receptors, which is common in patients with renal insufficiency or when overdose occurs. Clinicians should be alert to such adverse neurological events to ensure safe medication.

Key words: Piperacillin Sodium and Tazobactam Sodium for Injection, AECOPD, Convulsions, Dyspnea, γ-Aminobutyric Acid (GABA) Receptors, Adverse Drug Reaction

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