中国药物警戒 ›› 2026, Vol. 23 ›› Issue (10): 1195-1200.
DOI: 10.19803/j.1672-8629.20260597

• 综述 • 上一篇    

基于“益气活血通络”治法的木丹颗粒防治糖尿病微血管病变研究进展

王思瑶, 蔡茹霜, 易艳*   

  1. 中国中医科学院中草药中精神活性物质发现与防控北京市重点实验室,中药安全用药风险评控与转化重点实验室,中药研究所,北京 100700
  • 收稿日期:2026-07-17 出版日期:2026-10-15 发布日期:2026-10-16
  • 通讯作者: *易艳,女,博士,副研究员,中药药理与毒理研究。E-mail: yyi@icmm.ac.cn
  • 作者简介:王思瑶,女,在读硕士,中药药理与毒理研究。
  • 基金资助:
    道地药材品质保障与资源持续利用全国重点实验室科研专项项目（CI2024E003KC-11）;中国中医科学院科技创新工程成果贡献项目（CI2026GX0001）;中央级公益性科研院所基本科研业务费专项资金资助（ZXKT25036）;国家自然科学基金资助项目（82304814）;北京市中医药科技发展资金项目（BJZYYB-2025-21）

Research progress in the prevention and treatment of diabetic microangiopathy with Mudan granules based on the therapeutic principle of “tonifying qi, activating blood, and unblocking meridians”

Wang Siyao, Cai Rushuang, Yi Yan*   

  1. China Academy of Chinese Medical Sciences, Beijing Key Laboratory of Psychoactive Substances Discovery and Control in Chinese Herbal Medicines, Key Laboratory of TCM Safety Risk Assessment and Translation, Institute of Chinese Materia Medica, Beijing 100700, China
  • Received:2026-07-17 Online:2026-10-15 Published:2026-10-16

PDF (PC)

31

增强发表(附录)

1

摘要： 目的 基于“益气活血通络”治法,系统综述木丹颗粒防治糖尿病微血管病变的研究进展,为木丹颗粒在糖尿病微血管病变中的应用提供参考。方法 检索中国知网、PubMed等数据库中有关木丹颗粒的文献,对木丹颗粒防治糖尿病微血管病变的物质基础、临床应用、作用机制的研究进行分析和综述。结果 木丹颗粒含有皂苷类、黄酮类、生物碱类及酚酸类等多类活性成分群,可通过调控TLR4/NF-κB等炎症通路、抑制TGF-β1/Smad纤维化信号等多靶点协同,减轻炎症与氧化应激、延缓纤维化、改善胰岛素抵抗与微循环障碍,对多种糖尿病微血管病变呈现“异病同治”的药效特点。目前临床研究多支持其与西药联用的协同增效作用,且安全性良好。结论 木丹颗粒在糖尿病微血管病变防治中具有明确应用价值,但现有研究仍存在高质量循证证据不足、微观机制与中医“通络”内涵的关联尚待深入阐释等问题。未来应开展更多严谨的临床研究,深入探索“益气活血通络”的现代生物学基础,推动其在糖尿病微血管病变综合防治中的更广泛应用。

关键词: 木丹颗粒, 糖尿病微血管病变, 益气活血通络, 糖尿病周围神经病变, 糖尿病肾病, 中西医结合

Abstract: Objective To review the advances in research on the efficacy of Mudan granules in the prevention and treatment of diabetic microangiopathy based on the principle of “tonifying qi, activating blood, and unblocking meridians” in order to provide a reference for their clinical application. Methods Literature on Mudan granules was retrieved from such databases as CNKI and PubMed. The material basis, clinical applications, and mechanisms of action of Mudan granules in the prevention and treatment of diabetic microangiopathy were analyzed. Results Mudan granules contained multiple active compounds, including saponins, flavonoids, alkaloids, and phenolic acids. Through such mechanisms as regulating inflammatory pathways like TLR4/NF-κB and inhibiting fibrotic signals like TGF-β1/Smad, these granules could alleviate inflammation and oxidative stress, delay fibrosis, and improve insulin resistance and microcirculatory disturbances, with the properties of “the same treatment for different diseases” in diabetic microangiopathy. Current clinical studies mostly support the synergistic action of this drug when combined with Western medicine, along with a favorable safety profile. Conclusion Mudan granules have proved to be effective against diabetic microangiopathy. However, current research is facing such problems as insufficient high-quality evidence and poor understanding of the connection between the micro-level mechanisms and the connotation of “unblocking meridians” in TCM. More studies are needed to elucidate the modern biological basis of “tonifying qi, activating blood, and unblocking meridians” in order to popularize this formula in the comprehensive prevention and management of diabetic microangiopathy.

Key words: Mudan Granules, Diabetic Microangiopathy, Tonifying Qi, Activating Blood, and Unblocking Meridians, Diabetic Peripheral Neuropathy, Diabetic Nephropathy, Integrative Medicine

中图分类号: