中国药物警戒 ›› 2025, Vol. 22 ›› Issue (3): 334-336.
DOI: 10.19803/j.1672-8629.20240411

• 安全与合理用药 • 上一篇    下一篇

非奈利酮片致贫血1例分析

刘辰霈1,2, 杜雨芃3, 林燕1,2,*   

  1. 1天津中医药大学第一附属医院肾病科,天津 300382;
    2国家中医针灸临床医学研究中心肾病科,天津 300382;
    3天津医科大学研究生院,天津 300070
  • 收稿日期:2024-06-18 出版日期:2025-03-15 发布日期:2025-03-17
  • 通讯作者: *林燕,女,博士,主任医师•硕导,慢性肾脏病中医临床及机制。E-mail: liny7154@163.com
  • 作者简介:刘辰霈,男,硕士,慢性肾脏病中医临床及机制。
  • 基金资助:
    国家自然科学基金资助项目（81373609）;国家中医药管理局曹式丽全国名老中医药专家传承工作室建设项目（国中医药人教函〔2012〕149号）;国家中医药管理局第四批全国中医临床优秀人才研修项目（国中医药人教发〔2017〕124号）;天津市名中医林燕传承工作室建设项目（tjmzy2404）

One Case of Anemia Caused by Finerenone Tablets

LIU Chenpei1,2, DU Yupeng3, LIN Yan1,2,*   

  1. 1Department of Nephrology, First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300382, China;
    2Department of Nephrology, National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion,Tianjin 300382, China;
    3Graduate School, Tianjin Medical University, Tianjin 300070, China
  • Received:2024-06-18 Online:2025-03-15 Published:2025-03-17

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摘要： 目的 分析非奈利酮片致贫血的不良反应,为临床医师合理应用非奈利酮提供参考。方法 结合现有研究,对1例疑似由非奈利酮片导致血红蛋白（HGB）下降的糖尿病肾病（DKD）患者诊治经过、危险因素、可能机制及防治策略进行分析总结。结果 1例DKD患者服用非奈利酮片4个月后出现HGB下降,药物剂量增加后HGB进一步降低,经关联性评价,推测患者贫血可能由非奈利酮片所致,患者停药后HGB逐步回升。结论 临床应加强非奈利酮片致贫血不良反应的重视,做到尽早识别并及时干预,防止严重不良反应的发生。

关键词: 非奈利酮, 糖尿病肾病, 血红蛋白, 贫血, 药品不良反应

Abstract: Objective To analyze anemia caused by finerenone based on a case report in order to provide a reference for rational use of finerenone. Methods The treatment process, risk factors, possible mechanism and treatment regimens related to a diabetic kidney disease (DKD) patient with hemoglobin decline that was believed to have been caused by finerenone were analyzed based on research currently available. Results A DKD patient experienced hemoglobin decline after taking finerenone for four months. With an increase in drug dosage, the patient’s hemoglobin continued to decrease. With a Naranjo’s score of 8, the patient’s anemia was considered to have been caused by finerenone. After the patient discontinued the drug, hemoglobin gradually recovered during follow-up. Conclusion Clinicians should be alert to finerenone-induced anemia. Early identification and immediate interventions are crucial to preventing serious adverse drug reactions.

Key words: Finerenone, Diabetic Kidney Disease, Hemoglobin, Anemia, Adverse Drug Reactions

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