自噬在病变肝脏中不同功能的研究

doi:10.19803/j.1672-8629.20240725

摘要/Abstract

摘要： 目的探讨自噬在病变肝脏中起到的不同作用,为肝脏病变研究提供参考。方法查阅中国知网和PubMed等从建库截至2024年5月31日,汇总自噬在病变肝脏中的不同作用,包括肝损伤、肝纤维化和肝癌中承担的不同作用。结果在肝脏炎症的发展过程中,适度自噬可以通过减少肝细胞焦亡、减少脂滴聚集等维持肝脏中正常组织的动态平衡缓解肝损伤;自噬在病毒性肝炎中具有双向调控的作用;在肝纤维化过程中,自噬通过不同的作用机制来抑制或者促进纤维化的进展;自噬在肝癌发展的不同时期的发挥不同作用。结论肝损伤在病变肝脏中,自噬参与多种疾病的发生,研究自噬在肝脏中的作用机制和进展具有一定的意义。

关键词: 自噬, 肝损伤, 肝纤维化, 肝癌, 作用机制, 酒精相关性肝病

Abstract: Objective To investigate the different roles of autophagy in lesioned livers and provide references for the study of liver lesions. Methods By reviewing a large amount of related literature published at home and abroad, the different roles of autophagy in lesioned livers were summarized, involving liver injury, liver fibrosis and liver cancer. Results During the development of hepatitis, moderate autophagy could maintain the dynamics of normal tissues of the liver by reducing hepatocyte pyroptosis and lipid droplet aggregation. Autophagy was found to exert a bidirectional regulatory effect in viral hepatitis. In liver fibrosis, autophagy could inhibit or promote the development of fibrosis through different mechanisms of action. However, autophagy played different roles in different stages of liver cancer. Conclusion In diseased livers, autophagy is involved in the occurrence and development of a variety of diseases so that studies on autophagy are of great significance for the study of liver diseases.

Key words: Autophagy, Liver Damage, Hepatic Fibrosis, Hepatocarcinoma, Mechanism of Action, Alcohol-related Liver Disease

中图分类号:

R975
R994.11

王映荷, 李明奇, 赵晓璐, 马月宏. 自噬在病变肝脏中不同功能的研究[J]. 中国药物警戒, 2025, 22(8): 956-960.

WANG Yinghe, LI Mingqi, ZHAO Xiaolu, MA Yuehong. Different Functions of Autophagy in Diseased Livers[J]. Chinese Journal of Pharmacovigilance, 2025, 22(8): 956-960.

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https://zgywjj.magtechjournal.com/CN/Y2025/V22/I8/956

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