中国药物警戒 ›› 2025, Vol. 22 ›› Issue (6): 699-701.
DOI: 10.19803/j.1672-8629.20240798

• 安全与合理用药 • 上一篇    下一篇

复方聚乙二醇电解质散致缺血性肠炎1例分析

卢靖1,2, 蔡磊1, 童菲1, 于长辉1, 付顺军1, 潘明新1*   

  1. 1南方医科大学珠江医院肝胆二科,广东 广州 510280;
    2广州市荔湾中心医院药剂科,广东 广州 510170
  • 收稿日期:2024-10-17 发布日期:2025-06-18
  • 通讯作者: *潘明新,男,博士,教授,主任医师,肝病研究。E-mail: pmxwxy@sohu.com
  • 作者简介:卢靖,男,硕士,主管药师,临床药学。
  • 基金资助:
    PSM广东药学科普研究基金（2024KP108）

One Case of Ischemic Colitis Caused by Compound Polyethylene Glycol Electrolyte Powder

LU Jing1,2, CAI Lei1, TONG Fei1, YU Changhui1, FU Shunjun1, PAN Mingxin1*   

  1. 1Department Two of Hepatobiliary Surgery, Zhujiang Hospital, Southern Medical University, Guangzhou Guangdong 510280, China;
    2Department of Pharmacy, Liwan Central Hospital, Guangzhou Guangdong 510170, China
  • Received:2024-10-17 Published:2025-06-18

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摘要： 目的 探讨临床使用复方聚乙二醇电解质散进行肠道准备时引起缺血性肠炎（IC）病例,为临床用药安全提供参考。方法 分析复方聚乙二醇电解质散用于肠道准备后,发生IC的诊疗经过。对相关文献进行归纳与总结,分析诱导该患者发生IC的可能药物、机制及处理措施。结果 排除患者自身疾病、合并用药、肠镜检查操作等因素,判断复方聚乙二醇电解质散引起患者IC的相关性为“很可能”,经对症治疗后,患者逐渐好转。结论 IC是聚乙二醇电解质溶液的罕见不良反应,临床发现患者出现IC的早期症状时,在排除其他原因后,应考虑聚乙二醇电解质溶液诱导IC的可能并及时实施治疗干预。

关键词: 聚乙二醇电解质, 肠道准备, 缺血性肠炎, 肠镜检查, 药品不良反应

Abstract: Objective To study one case of ischemic colitis (IC) caused by compound polyethylene glycol electrolyte powder so as to provide a reference for safe medication. Methods The process of diagnosis and treatment of one case of IC that occurred after compound polyethylene glycol electrolyte powder was used for bowel preparation was analyzed. Based on related literature, drugs that might have induced IC in this patient were identified before the possible mechanisms and treatments were explored. Results The adverse reaction of the patient was diagnosed as IC. After such factors as the patient’s underlying diseases, concomitant medications, and colonoscopy were excluded, the correlations between compound polyethylene glycol electrolyte powder and IC were considered “probable”. After symptomatic treatment, the patient gradually improved. Conclusion IC is a rare adverse reaction caused by polyethylene glycol electrolyte solution. When early symptoms of IC are found in patients, the chances of IC induced by polyethylene glycol electrolyte solution should be considered and therapeutic interventions implemented quickly.

Key words: Polyethylene Glycol Electrolyte, Bowel Preparation, Ischemic Colitis, Colonoscopy, Adverse Drug Reaction

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