中国药物警戒 ›› 2025, Vol. 22 ›› Issue (6): 696-698.
DOI: 10.19803/j.1672-8629.20240711

• 安全与合理用药 • 上一篇    下一篇

注射用盐酸多西环素致患儿黑毛舌1例分析

陶兴茹1, 段彦彦1, 刘晓玲1, 刘月梅2, 张胜男1   

  1. 1郑州大学附属儿童医院药学部,河南 郑州 450000;
    2郑州大学附属儿童医院呼吸科,河南 郑州 450000
  • 收稿日期:2024-09-12 发布日期:2025-06-18
  • 作者简介:陶兴茹,女, 硕士,副主任药师,临床药学。E-mail: taoxr2010@sina.cn
  • 基金资助:
    河南省医学科技攻关计划（LHGJ20230587）

One Case of Black Hairy Tongue Caused by Doxycycline

TAO Xingru1, DUAN Yanyan1, LIU Xiaoling1, LIU Yuemei2, ZHANG Shengnan1   

  1. 1Department of Pharmacy, Zhengzhou University Affiliated Children's Hospital, Zhengzhou Henan 450000, China;
    2Respiratory Department, Zhengzhou University Affiliated Children's Hospital, Zhengzhou Henan 450000, China
  • Received:2024-09-12 Published:2025-06-18

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摘要： 目的 探讨多西环素导致黑毛舌不良反应特征及影响因素,为临床安全用药提供参考。方法 分析1例使用注射用盐酸多西环素导致黑毛舌病例,结合既往文献提出用药建议。结果 1例囊性纤维化患儿使用注射用盐酸多西环素18 d后出现舌背中部色素沉着,停用该药后症状逐渐消失,分析其因果关系,同时查阅国内外相关文献和病例报告,提示患儿出现该不良反应与多西环素很可能相关。结论 临床应用多西环素过程中应关注多西环素引起黑毛舌的风险,重点关注存在口腔微生态失衡、有基础疾病、免疫力较低及长期大量使用抗菌药物的患者。建议在用药期间加强口腔护理监测,出现色素沉着时应及时评估并调整治疗方案。

关键词: 多西环素, 儿童, 囊性纤维化, 黑毛舌, 药品不良反应

Abstract: Objective To investigate the characteristics of and contributing factors to doxycycline-induced black hairy tongue (BHT) and to provide references for safe clinical medication. Methods One case of BHT caused by doxycycline injection was analyzed based on literature review before recommendations about medication were given. Results A child with cystic fibrosis developed pigmentation on the mid-dorsal tongue after 18 days of doxycycline infusion. The symptoms were gradually improved after discontinuation of the drug. Causality analysis, combined with a review of related literature and case reports, indicated that this adverse reaction was likely associated with doxycycline. Conclusion Doxycycline, a widely used antimicrobial agent, carries the risk of inducing BHT. Clinicians should remain vigilant, particularly in patients with oral microbiome imbalances, underlying diseases, compromised immunity, or prolonged/high-dose antibiotic use. Enhanced oral care monitoring is recommended during treatment, and prompt assessment and regimen adjustment should be offered in case of pigmentation.

Key words: Doxycycline, Children, Cystic Fibrosis, Black Hairy Tongue, Adverse Drug Reactions

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