中国药物警戒 ›› 2025, Vol. 22 ›› Issue (5): 589-591.
DOI: 10.19803/j.1672-8629.20240776

• 安全与合理用药 • 上一篇    下一篇

大剂量地塞米松磷酸钠注射液致急性重度肝损伤1例分析

王丽1, 唐金玲2, 李翠红1, 谭飞龙1, 游丽娜1, 赵方允1,*   

  1. 1昆明医科大学附属延安医院药学部,云南 昆明 650051;
    2昆明医科大学附属延安医院全科医学科,云南 昆明 650051
  • 收稿日期:2024-10-08 出版日期:2025-05-15 发布日期:2025-05-19
  • 通讯作者: *赵方允,男,副主任药师,硕士,医院药学与药理学。E-mail: zhaofangyun@126.com
  • 作者简介:王丽,女,副主任药师,本科,医院药学与临床药学。
  • 基金资助:
    云南省高层次卫生计生技术人才培养经费资助项目(H-2019026)

One Case of Acute Severe Liver Injury Caused by High-Dose Dexamethasone Sodium Phosphate Injection

WANG Li1, TANG Jinling2, LI Cuihong1, TAN Feilong1, YOU Lina1, ZHAO Fangyun1,*   

  1. 1Departmen of Pharmacy, Yan’an Hospital Affiliated to Kunming Medical University, Kunming Yunnan 650051, China;
    2Department of General Practitioners, Yan’an Hospital Affiliated to Kunming Medical University, Kunming Yunnan 650051, China
  • Received:2024-10-08 Online:2025-05-15 Published:2025-05-19

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摘要： 目的 探讨地塞米松磷酸钠注射液致急性重度肝损伤的不良反应,为临床安全用药提供参考。方法 对1例原发免疫性血小板减少患者使用大剂量地塞米松磷酸钠注射液后出现急性重度肝损伤的病例,结合相关文献进行分析。结果 根据患者的临床表现、实验室检查及用药时间关联性,大剂量地塞米松磷酸钠注射液致急性重度肝损伤为很可能,后停用地塞米松磷酸钠注射液,更换为醋酸泼尼松片减量使用,肝损伤逐渐好转。但目前对糖皮质激素引起肝损伤的机制尚不清楚,需进一步研究明确。结论 临床在使用地塞米松磷酸钠注射液时要加强其不良反应监护,特别是大剂量使用时,应警惕肝损伤的不良反应。

关键词: 地塞米松磷酸钠, 注射液, 糖皮质激素, 剂量, 药品不良反应, 肝损伤

Abstract: Objective To analyze such adverse reactions as acute severe liver injury caused by glucocorticoids and provide a reference for clinical drug safety. Methods One case of acute severe liver injury that occurred after the administration of high-dose dexamethasone sodium phosphate injection in a patient with primary immune thrombocytopenia was analyzed in combination with related literature. Results Based on the patient’s clinical manifestations, results of laboratory tests, and the timing of drug administration, the patient’s acute severe liver injury was considered an adverse reaction caused by high-dose dexamethasone sodium phosphate injection. Conclusion Close monitoring of adverse reactions is critical when glucocorticoids are used clinically, especially at a high dose, and clinicians should be alert to such adverse reactions as liver injury.

Key words: Dexamethasone Sodium Phosphate, Injection, Glucocorticoid, Dose, Adverse Drug Reaction, Liver Injury

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