注射用替考拉宁和瑞巴派特片致血小板和白细胞减少1例分析

doi:10.19803/j.1672-8629.20240455

摘要/Abstract

摘要： 目的探讨注射用替考拉宁和瑞巴派特片致血小板和白细胞减少的临床特点及其可能的发生机制,为临床安全用药提供参考。方法通过分析1例使用注射用替考拉宁和瑞巴派特片致血小板和白细胞减少的病例,并检索相关文献,分析白细胞及血小板减少不良反应的特点及发生机制。结果患者分别在使用注射用替考拉宁和瑞巴派特片第2天出现血小板和白细胞减少,梳理患者用药并查阅药品说明书及相关文献,考虑血小板减少与注射用替考拉宁相关,白细胞减少与瑞巴派特片相关。建议临床停用相关药物,患者在停用注射用替考拉宁8天、停用瑞巴派特片4天,并予以输注血小板治疗后,血小板和白细胞计数逐渐恢复至正常范围。结论临床治疗过程中应关注注射用替考拉宁和瑞巴派特片有致血小板减少和白细胞减少不良反应的风险,若有相关反应,应及时停药,并给予对症处理,确保用药安全。

关键词: 注射用替考拉宁, 瑞巴派特片, 血小板减少, 白细胞减少, 药品不良反应

Abstract: Objective To investigate the clinical characteristics and possible mechanism of thrombocytopenia and leukopenia induced by teicoplanin and rebamipide and provide a reference for safe clinical use. Methods One case of thrombocytopenia and leukopenia induced by teicoplanin and rebamipide was reported. Based on related literature, the mechanism of adverse reactions was analyzed. Results The patient experienced thrombocytopenia and leukopenia after using teicoplanin and rabamipide for 2 days respectively. Clinical pharmacists traced the patient's medications and consulted the drug instructions and related literature before they concluded that thrombocytopenia was related to teicolanin, and leukopenia to rebabapide. Therefore, they recommended that these two drugs be discontinued. Eight days and four days after discontinuation of teicoplanin and rebamipide, respecvtively, platelet transfusion was given and the platelet and white blood cell counts gradually returned to normal. Conclusion Clinicians are to be alert to the risk of such adverse reactions as thrombocytopenia and leukopenia caused by teicoplanin and rebamipide. In case of adverse reactions, related drugs should be discontinued promptly and symptomatic treatment should be given to ensure safe medication.

Key words: Teicoplanin, Rebamipide, Thrombocytopenia, Leukopenia, Adverse Drug Reaction

中图分类号:

R973
R994.11

寇洁健, 王彦改. 注射用替考拉宁和瑞巴派特片致血小板和白细胞减少1例分析[J]. 中国药物警戒, 2025, 22(2): 227-230.

KOU Jiejian, WANG Yangai. One Case of Thrombocytopenia and Leukopenia Induced by Teicolanin and Rebabapide[J]. Chinese Journal of Pharmacovigilance, 2025, 22(2): 227-230.

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