中国药物警戒 ›› 2024, Vol. 21 ›› Issue (12): 1357-1362.
DOI: 10.19803/j.1672-8629.20240343

• 何首乌质量及安全性评价专栏（三） • 上一篇    下一篇

基于传统鉴别特征的何首乌质量评价研究进展

杨颜榕1, 康帅2△, 李妍怡3, 马双成4,5, 魏锋2, 王芳1#, 汪祺2,*   

  1. 1沈阳药科大学功能食品与葡萄酒学院,辽宁 沈阳 110016;
    2中国食品药品检定研究院中药民族药检定所,北京 100050;
    3北京中医药大学中药学院,北京 102488;
    4国家药典委员会,北京 100061;
    5药品监管科学全国重点实验室,北京 100061
  • 收稿日期:2024-05-24 出版日期:2024-12-15 发布日期:2024-12-16
  • 通讯作者: *汪祺,女,博士,研究员,中药质量与安全性评价。E-mail: sansan8251@sohu.com,#为共同通信作者。
  • 作者简介:杨颜榕,女,在读硕士,中药质量评价。△为并列第一作者。
  • 基金资助:
    国家自然科学基金资助项目（82374033）

Research Progress in Quality Evaluation of Polygonum multiflorum Thunb. Based on Features of Traditional Identification

YANG Yanrong1, KANG Shuai2△, LI Yanyi3, MA Shuangcheng4,5, WEI Feng2, WANG Fang1#, WANG Qi2,*   

  1. 1Shenyang Pharmaceutical University, School of Functional Food and Wine, Shenyang Liaoning 110016, China;
    2National Institutes for Food and Drug Control, Institute for Control of Chinese Traditional Medicine and Ethnic Medicine, Beijing 100050, China;
    3School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing 102488, China;
    4Chinese Pharmacopoeia Commission, Beijing 100061, China;
    5State Key Laboratong of Drug Regulatorg Science, Beijing 100061, China
  • Received:2024-05-24 Online:2024-12-15 Published:2024-12-16

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摘要： 目的 阐明何首乌性状及显微特征与其质量的相关性,建立科学评价何首乌质量的方法。方法 通过查阅文献和相关资料书籍,综述何首乌历史沿革和基原性状,明确有关赤白何首乌、云锦花纹、木心等性状特征与其质量的关联。结果 何首乌的正品基原应为蓼科植物何首乌（Polygonum multifonum Thunb.）的块根。何首乌木心的概念即断面中央木部或中央形成层环呈一圆形,云锦花纹和木心与其质量存在相关性。即云锦花纹明显、无木心的药材有效成分含量较高,云锦花纹小或无云锦、有木心的药材有效成分含量较低。结论 对于何首乌的赤白仍然存在争议,未能统一,由于现有的研究不充分,无法明确将何首乌的性状与质量建立起关联,还需深入研究。

关键词: 何首乌, 基原考证, 性状, 云锦花纹, 木心, 质量, 辨状论质

Abstract: Objective To clarify the correlation between the characters and microscopic characteristics of Polygonum multiflorum Thunb. and its quality, and establish a method to evaluate the quality. Methods The history and basal traits of Polygonum multiflorum Thunb. were studied based on related literature and books. The correlations between the trait characteristics of “red and white” Polygonum multiflorum Thunb., cloudy pattern, wood center and its quality were explored. Results The authentic basal root of Polygonum multiflorum Thunb. should be Polygonum multifonum Thunb. of the family Polygonaceae. The wood center of Polygonum multiflorum Thunb. referred to the round-shaped central part or the central formation of the layer ring in the cross-section of the herb. There was a correlation between the cloudy pattern and wood center and the quality of Polygonum multiflorum Thunb. Herbs with an obvious cloudy pattern but no wood center had higher contents of effective ingredients while those with a small or no cloud pattern but with a wood center had lower contents. Conclusion The categorization of Polygonum multiflorum Thunb. into “red and white” types remains controversial.Studies are so far insufficient to definitively correlate traits with the quality of Polygonum multiflirum Thunb., so in-depth research is needed in this area.

Key words: Polygonum multiflorum Thunb., Primordial Examination, Traits, Cloudy Pattern, Wood Center, Quality, Differentiation of Symptoms

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