何首乌毒性物质基础及肝毒性机制研究进展

摘要/Abstract

摘要： 何首乌作为传统的中药材,临床应用极其普遍。随着何首乌肝毒性报道越来越多,其安全性日益受到重视。本文主要从临床案例、化学成分及毒性物质基础、毒性机制等方面对何首乌的肝毒性进行综述,为何首乌临床安全用药及肝毒性机制研究提供参考。

关键词: 何首乌, 肝毒性, 肝损伤, 毒性物质基础

Abstract: Polygonum multiflorum is a traditional Chinese medicine with commonly clinical application. With increasing cases of Polygonum multiflorum related hepatotoxicity reported, the drug safety problem has been received more and more attention. This article reviews the toxicity characteristics of Polygonum multiflorum from the aspects of clinical cases, chemical composition and toxic material basis, and hepatotoxicity mechanism. We aim to provide a useful reference for the clinical use and mechanism research of Polygonum multiflorum.

Key words: Polygonum multiflorum, hepatotoxicity, liver injury, toxic material basis

中图分类号:

R994.2

于瑞丽, 门伟婕, 周昆, 于英莉. 何首乌毒性物质基础及肝毒性机制研究进展[J]. 中国药物警戒, 2019, 16(8): 496-503.

YU Ruili, MEN Weijie, ZHOU Kun, YU Yingli. Research Progress on Toxic Material Basis and Hepatotoxicity Mechanism of Polygonum Multiflorum[J]. Chinese Journal of Pharmacovigilance, 2019, 16(8): 496-503.

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