运用全面触发工具监测心理卫生疾病住院患者药品不良事件

中国药物警戒 ›› 2019, Vol. 16 ›› Issue (6): 352-359.

• 安全性评价与合理用药 • 上一篇下一篇

运用全面触发工具监测心理卫生疾病住院患者药品不良事件

徐家玥, 胡巧织, 徐铤^*

四川大学华西医院药剂科,四川成都 610041

收稿日期:2019-07-12 修回日期:2019-07-12 出版日期:2019-06-20 发布日期:2019-07-12
通讯作者: 徐铤,男,博士,主任药师·硕导,临床药学与医院药师管理。E-mail：tingx2009@163.com
作者简介:徐家玥,女,本科,药师,临床药学。

Using Global Trigger Tool to Monitor Adverse Drug Events in Inpatients with Psychiatric Disorders

XU Jiayue, HU Qiaozhi, XU Ting^*

Department of Pharmacy, West China Hospital of Sichuan University, Sichuan Chengdu 610041, China

Received:2019-07-12 Revised:2019-07-12 Online:2019-06-20 Published:2019-07-12

摘要/Abstract

摘要： 目的运用全面触发工具（global trigger tool,GTT）对心理卫生疾病住院患者的药品不良事件（adverse drug event,ADE）进行监测,同时评估该工具的适用性。方法随机抽取四川大学华西医院心理卫生中心,出院日期在2015年1月1日至2015年12月31日的成年住院患者病历信息,每月50例共600例。使用针对心理卫生疾病患者ADE监测的31项触发器对病历进行翻查,确定ADE并对其进行严重程度分级。同时根据病历翻查结果对触发工具进行初步修订。结果共纳入600例患者,31项触发器中仅15项触发器阳性,触发器阳性频次776次,其中379次为涉及ADE的有效触发,去重后共监测到281个ADE,其中仅25个ADE考虑为可预防性的。ADE/1 000患者天为26.96,ADE/100例患者为46.83%,243例患者至少发生过一次ADE,占总人数的40.50%。根据上述结果,建议可在原有触发工具中新增两项新触发器,并对一项触发器进行本土化修订。结论全面触发工具在监测心理卫生疾病患者药品不良事件方面适用性较强,可为防范用药风险提供参考,在我国心理卫生疾病相关的医疗机构有推广价值,但该工具仍需改进以适应本区域心理卫生疾病患者药品不良事件的监测。

关键词: 全面触发工具, 心理卫生疾病患者, 药品不良事件

Abstract: Objective To use the global trigger tool (GTT) to monitor adverse drug events (ADEs) of inpatients with psychiatric disorders and evaluate the applicability of the tool. Methods Medical record informations of adult inpatients discharged from the Mental Health Center of West China Hospital, Sichuan University from January 1, 2015 to December 31, 2015 were randomly selected, with a total of 600 cases (50 cases per month). Medical records were reviewed using 31 triggers for ADE monitoring in patients with psychiatric disorders to determine ADE and grade its severity. At the same time, the trigger tool was preliminarily revised according to the Results of the medical record search. Results A total of 600 patients were included in this study, only 15 of the 31 triggers were positive, with a positive frequency of 776 times. Among them, 379 times were effective triggers involving ADE, and a total of 281 ADEs were detected after repeated removal, of which only 25 ADEs were considered to be preventable. ADE/1 000 patients days were 26.96, ADE/100 patients were 46.83%, and 243 patients had ADE at least once, accounting for 40.50% of the total number of patients. Based on the above Results, it is recommended to add two new triggers to the original trigger tool and localize one trigger. Conclusion The global trigger tool has a strong applicability in monitoring adverse drug events of patients with psychiatric disorders, and can provide reference for preventing drug risks. It is worthy to be popularized in medical institutions related to mental health diseases in China, but the tool still needs to be improved to adapt to the monitoring of adverse drug events in patients with psychiatric disorders in this region.

Key words: global trigger tool, patients with psychiatric disorders, adverse drug events

中图分类号:

R994.11

徐家玥, 胡巧织, 徐铤. 运用全面触发工具监测心理卫生疾病住院患者药品不良事件[J]. 中国药物警戒, 2019, 16(6): 352-359.

XU Jiayue, HU Qiaozhi, XU Ting. Using Global Trigger Tool to Monitor Adverse Drug Events in Inpatients with Psychiatric Disorders[J]. Chinese Journal of Pharmacovigilance, 2019, 16(6): 352-359.

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运用全面触发工具监测心理卫生疾病住院患者药品不良事件

Using Global Trigger Tool to Monitor Adverse Drug Events in Inpatients with Psychiatric Disorders

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