慢性肾脏病住院患者使用抗菌药物应用特点的分析

中国药物警戒 ›› 2018, Vol. 15 ›› Issue (9): 550-554.

慢性肾脏病住院患者使用抗菌药物应用特点的分析

陈湉傲^1,2, 刘晓¹, 梁雁^1*

¹北京大学第一医院药剂科,北京 100034;
²中国药科大学基础医学与临床药学学院,江苏南京 211198

收稿日期:2018-11-02 修回日期:2018-11-02 出版日期:2018-09-20 发布日期:2018-11-02
通讯作者: 梁雁,女,硕士,主任药师,临床药学和临床药理学。E-mail：liangyan973@126.com
作者简介:陈湉傲,女,在读硕士,临床药学。

Analysis on Characteristics of Antibacterial Use in Inpatients with Chronic Kidney Disease

CHEN Tianao^1,2, LIU Xiao¹, LIANG Yan^1*

¹Department of Pharmacy, The First Hospital, Peking University, Beijing 100034, China;
²School of Basic Medicine and Clinical Pharmacy, China Pharmaceutical University, Nanjing Jiangsu 211198, China

Received:2018-11-02 Revised:2018-11-02 Online:2018-09-20 Published:2018-11-02

摘要/Abstract

摘要： 目的通过对慢性肾脏病（chronic kidney disease,CKD）患者使用抗菌药物进行调查,评价其用药安全性,为临床应用抗菌药物提供参考。方法回顾性分析我院2014年1月至10月慢性肾脏病住院患者抗菌药物的使用情况,包括患者基本情况,抗菌药物使用情况、药品不良反应等,录入Excel中并进行统计分析。结果 1 793例慢性肾脏病住院患者中,感染发生率为20.86%,以呼吸和泌尿系统感染为主。有495例患者使用抗菌药物,使用抗菌药物579例次,其中治疗用345例次,预防用150例次。在治疗用药中有69.52%的患者进行了病原菌检测。在抗菌药物的患者中,使用喹诺酮类和头孢菌素类抗菌药物居前两位。抗菌药物联合用药66例,不良反应22例,消化系统的不良反应居首位。结论慢性肾脏病患者使用抗菌药物的不良反应发生率正常,临床医生在抗菌药物使用过程中应注意根据肾脏情况调整给药方案。

关键词: 慢性肾脏病, 抗菌药物, 安全性

Abstract: Objective To investigate the use of antibacterials in patients with chronic kidney disease(CKD) and evaluate the drug safety for providing some clinical reference. Methods Inpatients with CKD over a 10-month period from January to October, 2014 in our hospital were analyzed retrospectively. Results In the 1 793 cases of hospitalized patients with CKD, the incidence of infection was 20.86%, mainly respiratory and urinary tract infections. 495 cases were treated with antibacterials, 345 cases for treating and 150 cases for preventing. In cases for treating, pathogenic bacteria were detected in 69.52% of the patients. Quinolones and cephalosporins were the most commonly used antibacterials. There were 66 cases with drug combinations, 22 cases with adverse drug reactions, and the adverse reactions of digestive system were the most common. Conclusion Inpatients with CKD are basically safe to use antibiotics. The dosage regimen should be adjusted by renal condition in the clinic.

Key words: chronic kidney disease, antibacterials, safety

中图分类号:

R969.3

陈湉傲, 刘晓, 梁雁. 慢性肾脏病住院患者使用抗菌药物应用特点的分析[J]. 中国药物警戒, 2018, 15(9): 550-554.

CHEN Tianao, LIU Xiao, LIANG Yan. Analysis on Characteristics of Antibacterial Use in Inpatients with Chronic Kidney Disease[J]. Chinese Journal of Pharmacovigilance, 2018, 15(9): 550-554.

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