关键词: 肉桂, 成药, 用药规律, 不良反应

Abstract: Objective To summarize the drug prescription of cinnamon and to analyze the related (Adverse drug reactions; ADR), and to provide reference for the rational use of drugs for diagnosis and treatment. Methods Cinnamon (oil) preparations were selected from the Chinese pharmacopoeia (2015 edition) and "Pharmacology of traditional Chinese medicine" ("Twelfth Five-Year", second edition) and retrieved from the 1962-2017 China Journal Full-Text Database (CNKI) and statistically relevant adverse drug reactions was calculated. Results A total of 50 cinnamon prescriptions, 1 single preparation, 285 proprietary Chinese medicines, and 30 adverse reactions were collected. Between 2000 and 2009 there were more distributions (40.7%); Most of the adverse reactions were type A, suggesting a predictable and dose-dependent characteristic. The incidence of reaction in the young and middle-aged patients was high (80%), mainly affecting the skin and its accessories and sensory system. The high frequency occurred within 60 minutes of drug use, 3 ~ 7 days of drug use, within 3 months of drug use and several months to six months of drug use. Conclusion The main causes of adverse reactions are related to compatibility, syndrome differentiation, abuse, misuse, and occupational diseases. Conclusion The reasons of ADR are mainly related to herb compatibility, wrong syndrome differentiation, misuse and occupational disease.

Key words: Cinnamon, Chinese patent medicine preparation, regularity, adverse drug reaction