关键词: 右旋雷贝拉唑钠, 单次给药毒性, 近似致死量, Beagle犬

Abstract: Objective To study the single-dose toxicity of dexrabeprazole sodium in Beagle dogs and compare the toxicity of dexrabeprazole sodium with rabeprazole sodium. Methods Approximate lethal dose methods were adopted to evaluate the single-dose toxicity of dexrabeprazole sodium in Beagle dogs. Animals were divided into different groups and were administered with different dose for one time. The general symptoms were observed and body weight, hematology, blood biochemistry and histopathology were detected after administration. The animals were autopsied and lesion of main organs were observed after continuous observation for 14 days. Results The approximate lethal doses of dexrabeprazole sodium and rabeprazole sodium in Beagle dog are 192.2~288.3 mg·kg^-1 and 128.1~192.2 mg·kg^-1 respectively. The main acute toxicity symptoms of dead dogs are salivation, vomiting, weakness of limbs, tremble, tachypnea, prone position, convulsion, somatic rigidity, and eventually to death. Conclusion The toxic reactions of dexrabeprazole sodium in Beagle dogs are similar to that of rabeprazole sodium, but the toxicity level is higher than that of rabeprazole sodium .

Key words: dexrabeprazole sodium, single-dose toxicity, approximate lethal dose, Beagle dog