中国药物警戒 ›› 2016, Vol. 13 ›› Issue (8): 500-502.

• 安全性评价与合理用药 • 上一篇    下一篇

注射用利福平在6种溶媒中的稳定性考察

侯文洁, 丁红梓, 周秋云, 王洁*   

  1. 东南大学医学院附属南京胸科医院药学部,江苏 南京 210029
  • 收稿日期:2016-09-14 修回日期:2016-09-14 出版日期:2016-08-20 发布日期:2016-09-14
  • 通讯作者: 王洁,女,主任药师,临床药学。E-mail: 13905165431@163.com.

Stability Study of Rifampin for Injection in Six Solvents

HOU Wen-jie, DING Hong-zi, ZHOU Qiu-yun, WANG Jie*   

  1. Department of Pharmacy, Nanjing Chest Hospital, Southeast University, Jiangsu Nanjing 210029, China
  • Received:2016-09-14 Revised:2016-09-14 Online:2016-08-20 Published:2016-09-14

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摘要： 目的 探讨利福平在6种溶媒中的稳定性。方法 利福平分别和6种溶媒配伍后,采用RP-HPLC 法对不同温度及不同时间下的样品含量进行检测。结果 利福平在500 mL 0.9%氯化钠注射液和500 mL 5%葡萄糖注射液中的浓度没有显著改变,在其他溶媒中浓度随着温度升高和时间延长均出现了不同程度的下降。结论 500 mL 0.9%氯化钠注射液和500 mL 5%葡萄糖注射液是最适合利福平的溶媒。

关键词: 利福平, 溶媒, 配伍稳定性

Abstract: Objective To investigate the stability of rifampin in six solvents. Methods After the samples of rifampin were dissolved in six solvents, RP-HPLC was employed to analyze the contents at different time and temperature. Results The concentration of rifampin had no significant change in 0.9% NS and 5% GS with the volume of 500 mL. However, the decline of the content of rifampinin was observed with increased temperature and extended time. Conclusion It may be beneficial to make up rifampin in 0.9% NS and 5% GS with the volume of 500 mL.

Key words: rifampin, solvent, compatible stability

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