关键词: 棓丙酯注射液, 输液, 配伍, 稳定性

Abstract: Objective To study the stability of the solution after compatibility of the propylgallate injection with different transfusions, so as to provide favorable experimental basis for the clinical application of the propylgallate injection. Methods According to the requirements for simulation of clinical medicine, the transfusions were divided into experimental group and control group, and the changes of color, pH values, and particle numbers of compatible solutions at 0, 0.5, 1, 2, 4 h and 8 h were investigated. The numbers of particles were detected by light blockage method specified in Chinese Pharmacopeia (2015 edition, No 4). Results The compatible solutions of propylgallate injection at different time were transparent liquid, no obvious change, and there were no differences between the groups. The pH value remained stable. The numbers of particles increaseed or decreaseed with time, which reached the minimum floating when propylgallate injection combined with 5% and 10% glucose injection, conformed to the 2015 edition of Chinese Pharmacopoeia standards. The numbers of≥10 µm particles quickly increased and exceeded the limitation of the Chinese Pharmacopoeia after combined with 0.9% sodium chloride injection. The numbers of≥10 µm particles reached the maximum floating at 0 hour when propylgallate injection combined with glucose-sodium chloride injection. At other times, the numbers of insoluble particles were qualified. Conclusion The most compatible suitable solvents for propylgallate injection were 5% glucose injection and 10% glucose injection.

Key words: propylgallate injection, transfusion, combination, stability