中国药物警戒 ›› 2016, Vol. 13 ›› Issue (4): 236-239.

• 安全性评估与合理用药 • 上一篇    下一篇

广东省四地市医疗机构参麦注射液不合理用药情况分析

吴斌1,吴建茹1,钟翎1,林宇2,张业象2   

  1. 1深圳市药品不良反应监测中心,广东 深圳 518029;
    2广东省药品不良反应监测中心,广东 广州 510080
  • 收稿日期:2016-03-11 修回日期:2016-06-30 出版日期:2016-04-20 发布日期:2016-06-30
  • 通讯作者: 钟翎,女,博士,教授·硕导,药物警戒。E-mail:zhongling@szda.gov.cn
  • 作者简介:吴斌,女,本科,副主任药师,药物警戒。
  • 基金资助:
    深圳市科技研发基金项目（JCYJ20130401143657823）;广东省科技基础条件建设项目（2012B060500050）。

Analysis of Irrational Application of Shenmai Injections in Four Cities in Guangdong

WU Bin1, WU Jian-ru1, ZHONG Ling1,* LIN Yu2, ZHANG Ye-xiang2   

  1. 1.Center for ADR Monitoring of Shenzhen, Guangdong Shenzhen 518034 China;
    2.Center for ADR Monitoring of Guangdong, Guangdong Guangzhou 510080, China
  • Received:2016-03-11 Revised:2016-06-30 Online:2016-04-20 Published:2016-06-30

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摘要： 目的 通过对广东省四地市基层医疗机构基本药物参麦注射剂的主动监测,获得参麦注射液在日常现实使用操作中的情况后,分析其不合理用药的情况,为提高基层合理用药提供依据和指导。方法 采用前瞻性病例系列研究方法对广东省四地市13家医院2 402例使用参麦注射液的患者进行调查和数据分析。结果 一级医院不合理用药率（82.64%）高于二级医院不合理用药率（76.45%）,且存在统计学分析上的显著差异（χ2=6.66, P=0.0099）。不合理用药主要表现为超适应证用药、溶媒使用不当、浓度过大、合并用药。其中,一级医院超适应证用药为1 565例,占74.21%;二级医院超适应证用药为138例,占47.10%。结论 广东省四地市医疗机构参麦注射液不合理用药情况较为严重,应加强对基层医疗机构的合理用药干预及对医生的用药指导。

关键词: 参麦注射液, 不合理用药, 统计学分析

Abstract: Objective To achieve the rational application of Shenmai injections through active monitoring and to analyze irrational application in daily practices, so as to establish the effective guidance for the basic-grade hospitals at 4 city areas of Guangdong province. Methods A method of prospective case series study was designed to inquire total of 2 402 patients who were injected Shenmai injections in 13 basic-grade hospitals at 4 city areas of Guangdong province. Results Statistic analysis indicated that the level of irrational application of Shenmai injections in the grade I hospitals 82.64% was significantly higher χ2=6.66, P=0.0099 than that in the grade II hospitals 76.45%. The major performances of irrational applications included: injections with over doses, incorrect selections of solvent, over-high concentrations and improper combinations of drugs. Over dose application rate of Shenmai injections in hospitals of the grade I and the grade II were 74.21% and 47.10%, respectively. Conclusion The irrational application of Shenmai injections in hospitals at 4 city areas of Guangdong province is a serious problem. Practical guidance in rational use of the drug and the guide for doctors in primary hospitals should be strengthened.

Key words: Shenmai injection, irrational application, statistic analysis

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